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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & MCFold [.zip] - may take several seconds...


Overview

Metric TurboFold(20) MCFold
MCC 0.650 > 0.498
Average MCC ± 95% Confidence Intervals 0.669 ± 0.323 > 0.525 ± 0.373
Sensitivity 0.612 > 0.534
Positive Predictive Value 0.700 > 0.478
Total TP 63 > 55
Total TN 7793 > 7768
Total FP 36 < 80
Total FP CONTRA 9 < 13
Total FP INCONS 18 < 47
Total FP COMP 9 < 20
Total FN 40 < 48
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and MCFold).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 63
Total TN 7793
Total FP 36
Total FP CONTRA 9
Total FP INCONS 18
Total FP COMP 9
Total FN 40
Total Scores
MCC 0.650
Average MCC ± 95% Confidence Intervals 0.669 ± 0.323
Sensitivity 0.612
Positive Predictive Value 0.700
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 55
Total TN 7768
Total FP 80
Total FP CONTRA 13
Total FP INCONS 47
Total FP COMP 20
Total FN 48
Total Scores
MCC 0.498
Average MCC ± 95% Confidence Intervals 0.525 ± 0.373
Sensitivity 0.534
Positive Predictive Value 0.478
Nr of predictions 5

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.