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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of MaxExpect - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & MaxExpect [.zip] - may take several seconds...


Overview

Metric TurboFold(20) MaxExpect
MCC 0.653 > 0.590
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244 > 0.601 ± 0.295
Sensitivity 0.606 > 0.591
Positive Predictive Value 0.714 > 0.600
Total TP 80 > 78
Total TN 9208 > 9190
Total FP 42 < 68
Total FP CONTRA 11 < 17
Total FP INCONS 21 < 35
Total FP COMP 10 < 16
Total FN 52 < 54
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and MaxExpect).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and MaxExpect).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 80
Total TN 9208
Total FP 42
Total FP CONTRA 11
Total FP INCONS 21
Total FP COMP 10
Total FN 52
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244
Sensitivity 0.606
Positive Predictive Value 0.714
Nr of predictions 6

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MaxExpect - scored lower in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 78
Total TN 9190
Total FP 68
Total FP CONTRA 17
Total FP INCONS 35
Total FP COMP 16
Total FN 54
Total Scores
MCC 0.590
Average MCC ± 95% Confidence Intervals 0.601 ± 0.295
Sensitivity 0.591
Positive Predictive Value 0.600
Nr of predictions 6

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.70 0.69 0.71 20 1505 8 3 5 0 9
4A1C_2 0.19 0.25 0.16 5 4484 41 10 17 14 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.85 0.73 1.00 11 461 0 0 0 0 4
4ENC_A 0.36 0.33 0.42 5 484 8 0 7 1 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.