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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of ProbKnot - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & ProbKnot [.zip] - may take several seconds...


Overview

Metric TurboFold(20) ProbKnot
MCC 0.653 > 0.577
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244 > 0.606 ± 0.261
Sensitivity 0.606 < 0.614
Positive Predictive Value 0.714 > 0.555
Total TP 80 < 81
Total TN 9208 > 9174
Total FP 42 < 82
Total FP CONTRA 11 < 26
Total FP INCONS 21 < 39
Total FP COMP 10 < 17
Total FN 52 > 51
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and ProbKnot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and ProbKnot).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 80
Total TN 9208
Total FP 42
Total FP CONTRA 11
Total FP INCONS 21
Total FP COMP 10
Total FN 52
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.668 ± 0.244
Sensitivity 0.606
Positive Predictive Value 0.714
Nr of predictions 6

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.22 0.25 0.21 5 4492 28 6 13 9 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 81
Total TN 9174
Total FP 82
Total FP CONTRA 26
Total FP INCONS 39
Total FP COMP 17
Total FN 51
Total Scores
MCC 0.577
Average MCC ± 95% Confidence Intervals 0.606 ± 0.261
Sensitivity 0.614
Positive Predictive Value 0.555
Nr of predictions 6

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.87 0.83 0.91 20 844 2 2 0 0 4
3SD1_A 0.66 0.69 0.65 20 1502 11 6 5 0 9
4A1C_2 0.17 0.25 0.13 5 4477 49 13 21 15 15
4AOB_A 0.60 0.59 0.63 17 1410 11 4 6 1 12
4ENB_A 0.81 0.73 0.92 11 460 1 1 0 0 4
4ENC_A 0.52 0.53 0.53 8 481 8 0 7 1 7

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.