CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & Carnac(20) [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) Carnac(20)
MCC 0.636 > 0.600
Average MCC ± 95% Confidence Intervals 0.664 ± 0.254 > 0.440 ± 0.395
Sensitivity 0.606 > 0.417
Positive Predictive Value 0.678 < 0.873
Total TP 80 > 55
Total TN 9202 < 9257
Total FP 51 > 10
Total FP CONTRA 14 > 2
Total FP INCONS 24 > 6
Total FP COMP 13 > 2
Total FN 52 < 77
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and Carnac(20)).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 80
Total TN 9202
Total FP 51
Total FP CONTRA 14
Total FP INCONS 24
Total FP COMP 13
Total FN 52
Total Scores
MCC 0.636
Average MCC ± 95% Confidence Intervals 0.664 ± 0.254
Sensitivity 0.606
Positive Predictive Value 0.678
Nr of predictions 6

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 55
Total TN 9257
Total FP 10
Total FP CONTRA 2
Total FP INCONS 6
Total FP COMP 2
Total FN 77
Total Scores
MCC 0.600
Average MCC ± 95% Confidence Intervals 0.440 ± 0.395
Sensitivity 0.417
Positive Predictive Value 0.873
Nr of predictions 6

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.72 0.55 0.94 16 1516 1 0 1 0 13
4A1C_2 0.42 0.25 0.71 5 4509 3 0 2 1 15
4AOB_A 0.59 0.48 0.74 14 1418 6 2 3 1 15
4ENB_A 0.00 0.00 0.00 0 472 0 0 0 0 15
4ENC_A 0.00 0.00 0.00 0 496 0 0 0 0 15

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.