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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of MCFold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & MCFold [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) MCFold
MCC 0.537 > 0.491
Average MCC ± 95% Confidence Intervals 0.548 ± 0.392 > 0.510 ± 0.284
Sensitivity 0.521 = 0.521
Positive Predictive Value 0.568 > 0.477
Total TP 63 = 63
Total TN 8300 > 8279
Total FP 60 < 90
Total FP CONTRA 15 > 13
Total FP INCONS 33 < 56
Total FP COMP 12 < 21
Total FN 58 = 58
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and MCFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and MCFold).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 63
Total TN 8300
Total FP 60
Total FP CONTRA 15
Total FP INCONS 33
Total FP COMP 12
Total FN 58
Total Scores
MCC 0.537
Average MCC ± 95% Confidence Intervals 0.548 ± 0.392
Sensitivity 0.521
Positive Predictive Value 0.568
Nr of predictions 6

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
3RKF_A 0.91 0.83 1.00 20 846 0 0 0 0 4
3SD1_A 0.71 0.69 0.74 20 1506 7 2 5 0 9
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4ENB_A 0.77 0.60 1.00 9 463 0 0 0 0 6
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of MCFold - scored lower in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP 63
Total TN 8279
Total FP 90
Total FP CONTRA 13
Total FP INCONS 56
Total FP COMP 21
Total FN 58
Total Scores
MCC 0.491
Average MCC ± 95% Confidence Intervals 0.510 ± 0.284
Sensitivity 0.521
Positive Predictive Value 0.477
Nr of predictions 6

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.44 0.47 8 511 10 0 9 1 10
3RKF_A 0.89 0.88 0.91 21 843 3 0 2 1 3
3SD1_A 0.43 0.45 0.43 13 1503 17 1 16 0 16
4A1C_2 0.18 0.25 0.14 5 4480 45 12 19 14 15
4ENB_A 0.78 0.73 0.85 11 459 4 0 2 2 4
4ENC_A 0.34 0.33 0.38 5 483 11 0 8 3 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.