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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & NanoFolder [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) NanoFolder
MCC 0.383 > 0.336
Average MCC ± 95% Confidence Intervals 0.391 ± 0.585 < 0.394 ± 0.460
Sensitivity 0.378 < 0.415
Positive Predictive Value 0.403 > 0.288
Total TP 31 < 34
Total TN 6900 > 6859
Total FP 59 < 101
Total FP CONTRA 15 < 25
Total FP INCONS 31 < 59
Total FP COMP 13 < 17
Total FN 51 > 48
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and NanoFolder).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 31
Total TN 6900
Total FP 59
Total FP CONTRA 15
Total FP INCONS 31
Total FP COMP 13
Total FN 51
Total Scores
MCC 0.383
Average MCC ± 95% Confidence Intervals 0.391 ± 0.585
Sensitivity 0.378
Positive Predictive Value 0.403
Nr of predictions 4

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.03 0.00 0.00 0 513 15 3 12 0 18
4A1C_2 0.20 0.25 0.17 5 4486 37 9 16 12 15
4AOB_A 0.67 0.59 0.77 17 1415 6 2 3 1 12
4ENC_A 0.73 0.60 0.90 9 486 1 1 0 0 6

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 34
Total TN 6859
Total FP 101
Total FP CONTRA 25
Total FP INCONS 59
Total FP COMP 17
Total FN 48
Total Scores
MCC 0.336
Average MCC ± 95% Confidence Intervals 0.394 ± 0.460
Sensitivity 0.415
Positive Predictive Value 0.288
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.54 0.61 0.50 11 506 11 1 10 0 7
4A1C_2 -0.01 0.00 0.00 0 4469 61 18 29 14 20
4AOB_A 0.39 0.41 0.39 12 1406 20 4 15 1 17
4ENC_A 0.66 0.73 0.61 11 478 9 2 5 2 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.