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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Afold - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Afold & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Afold PPfold(seed)
MCC 0.489 > 0.187
Average MCC ± 95% Confidence Intervals 0.547 ± 0.441 > 0.137 ± 0.359
Sensitivity 0.443 > 0.066
Positive Predictive Value 0.547 > 0.538
Total TP 47 > 7
Total TN 16721 < 16794
Total FP 52 > 25
Total FP CONTRA 6 > 0
Total FP INCONS 33 > 6
Total FP COMP 13 < 19
Total FN 59 < 99
P-value 0.0

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Performance plots


  1. Comparison of performance of Afold and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Afold and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Afold and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Afold and PPfold(seed)).

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Performance of Afold - scored higher in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 47
Total TN 16721
Total FP 52
Total FP CONTRA 6
Total FP INCONS 33
Total FP COMP 13
Total FN 59
Total Scores
MCC 0.489
Average MCC ± 95% Confidence Intervals 0.547 ± 0.441
Sensitivity 0.443
Positive Predictive Value 0.547
Nr of predictions 4

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 6 0 5 1 9
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
4A1C_2 0.14 0.15 0.14 5 11745 43 5 26 12 28
4ENB_A 0.67 0.58 0.79 11 1261 3 1 2 0 8

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 7
Total TN 16794
Total FP 25
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 19
Total FN 99
Total Scores
MCC 0.187
Average MCC ± 95% Confidence Intervals 0.137 ± 0.359
Sensitivity 0.066
Positive Predictive Value 0.538
Nr of predictions 4

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.30 0.75 6 1532 2 0 2 0 14
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
4A1C_2 0.08 0.03 0.20 1 11776 23 0 4 19 32
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.