CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Alterna - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for Alterna & RNASLOpt [.zip] - may take several seconds...


Overview

Metric Alterna RNASLOpt
MCC 0.432 > 0.360
Average MCC ± 95% Confidence Intervals 0.348 ± 0.247 > 0.285 ± 0.259
Sensitivity 0.379 > 0.274
Positive Predictive Value 0.505 > 0.486
Total TP 47 > 34
Total TN 10610 < 10633
Total FP 46 > 36
Total FP CONTRA 8 > 2
Total FP INCONS 38 > 34
Total FP COMP 0 = 0
Total FN 77 < 90
P-value 0.0

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Performance plots


  1. Comparison of performance of Alterna and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Alterna and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Alterna and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Alterna and RNASLOpt).

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Performance of Alterna - scored higher in this pairwise comparison

1. Total counts & total scores for Alterna

Total Base Pair Counts
Total TP 47
Total TN 10610
Total FP 46
Total FP CONTRA 8
Total FP INCONS 38
Total FP COMP 0
Total FN 77
Total Scores
MCC 0.432
Average MCC ± 95% Confidence Intervals 0.348 ± 0.247
Sensitivity 0.379
Positive Predictive Value 0.505
Nr of predictions 6

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2. Individual counts for Alterna [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.46 0.40 0.53 8 1525 7 0 7 0 12
3J0L_g - -0.01 0.00 0.00 0 456 9 4 5 0 4
3J0L_7 - 0.26 0.24 0.31 4 1212 9 0 9 0 13
3J0L_a - 0.23 0.19 0.30 3 1118 7 1 6 0 13
3J16_L 0.63 0.53 0.76 16 2754 5 1 4 0 14
3UZL_B 0.52 0.43 0.64 16 3545 9 2 7 0 21

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 34
Total TN 10633
Total FP 36
Total FP CONTRA 2
Total FP INCONS 34
Total FP COMP 0
Total FN 90
Total Scores
MCC 0.360
Average MCC ± 95% Confidence Intervals 0.285 ± 0.259
Sensitivity 0.274
Positive Predictive Value 0.486
Nr of predictions 6

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.35 0.64 7 1529 4 0 4 0 13
3J0L_g - -0.01 0.00 0.00 0 461 4 1 3 0 4
3J0L_7 - -0.01 0.00 0.00 0 1212 13 0 13 0 17
3J0L_a - 0.26 0.19 0.38 3 1120 5 1 4 0 13
3J16_L 0.53 0.40 0.71 12 2758 5 0 5 0 18
3UZL_B 0.48 0.32 0.71 12 3553 5 0 5 0 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.