CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	CRWrnafold		MCFold
MCC	0.455	>	0.431
Average MCC ± 95% Confidence Intervals	0.412 ± 0.172	>	0.382 ± 0.150
Sensitivity	0.403	<	0.459
Positive Predictive Value	0.522	>	0.412
Total TP	157	<	179
Total TN	50754	>	50621
Total FP	159	<	291
Total FP CONTRA	16	<	38
Total FP INCONS	128	<	217
Total FP COMP	15	<	36
Total FN	233	>	211
P-value	2.35965341511e-08

Comparison of performance of CRWrnafold and MCFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CRWrnafold and MCFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for CRWrnafold and MCFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CRWrnafold and MCFold).

Total Scores
MCC	0.455
Average MCC ± 95% Confidence Intervals	0.412 ± 0.172
Sensitivity	0.403
Positive Predictive Value	0.522
Nr of predictions	14

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	-0.01	0.00	0.00	0	1525	15	2	13	0	20
2LKR_A	-	0.52	0.44	0.63	17	6078	12	2	8	2	22
3AMU_B	tRNA links to Rfam database...	0.67	0.59	0.76	16	2982	7	0	5	2	11
3J0L_g	-	-0.01	0.00	0.00	0	461	4	1	3	0	4
3J0L_2	-	0.25	0.24	0.28	8	6187	23	2	19	2	25
3J0L_a	-	0.39	0.31	0.50	5	1118	5	1	4	0	11
3J0L_7	-	-0.01	0.00	0.00	0	1212	13	0	13	0	17
3J16_L	tRNA links to Rfam database...	0.84	0.70	1.00	21	2754	0	0	0	0	9
3SD1_A	THF links to Rfam database...	0.52	0.45	0.61	19	3885	12	2	10	0	23
3U4M_B	-	0.38	0.32	0.46	12	3134	14	0	14	0	25
4A1C_2	5_8S_rRNA links to Rfam database...	0.13	0.15	0.13	5	11741	44	4	31	9	28
4A1C_3	5S_rRNA links to Rfam database...	0.70	0.59	0.84	32	7102	6	0	6	0	22
4ENB_A	crcB links to Rfam database...	0.70	0.58	0.85	11	1262	2	1	1	0	8
4ENC_A	crcB links to Rfam database...	0.70	0.58	0.85	11	1313	2	1	1	0	8

Total Scores
MCC	0.431
Average MCC ± 95% Confidence Intervals	0.382 ± 0.150
Sensitivity	0.459
Positive Predictive Value	0.412
Nr of predictions	14

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.41	0.45	0.39	9	1517	16	0	14	2	11
2LKR_A	-	0.93	0.92	0.95	36	6067	14	0	2	12	3
3AMU_B	tRNA links to Rfam database...	0.44	0.48	0.42	13	2972	18	2	16	0	14
3J0L_g	-	0.13	0.25	0.08	1	452	12	8	4	0	3
3J0L_2	-	0.21	0.24	0.18	8	6172	39	7	29	3	25
3J0L_a	-	0.16	0.19	0.17	3	1110	15	1	14	0	13
3J0L_7	-	-0.01	0.00	0.00	0	1206	19	4	15	0	17
3J16_L	tRNA links to Rfam database...	0.45	0.47	0.44	14	2743	19	1	17	1	16
3SD1_A	THF links to Rfam database...	0.33	0.33	0.35	14	3876	26	0	26	0	28
3U4M_B	-	0.59	0.59	0.59	22	3123	15	0	15	0	15
4A1C_2	5_8S_rRNA links to Rfam database...	0.13	0.15	0.11	5	11735	56	10	31	15	28
4A1C_3	5S_rRNA links to Rfam database...	0.68	0.67	0.71	36	7089	17	1	14	2	18
4ENB_A	crcB links to Rfam database...	0.61	0.63	0.60	12	1255	8	2	6	0	7
4ENC_A	crcB links to Rfam database...	0.28	0.32	0.27	6	1304	17	2	14	1	13

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.