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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Carnac(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Carnac(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric Carnac(20) NanoFolder
MCC 0.506 > 0.316
Average MCC ± 95% Confidence Intervals 0.373 ± 0.454 > 0.345 ± 0.403
Sensitivity 0.318 < 0.324
Positive Predictive Value 0.810 > 0.316
Total TP 47 < 48
Total TN 24560 > 24466
Total FP 13 < 114
Total FP CONTRA 1 < 15
Total FP INCONS 10 < 89
Total FP COMP 2 < 10
Total FN 101 > 100
P-value 0.0

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Performance plots


  1. Comparison of performance of Carnac(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Carnac(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Carnac(20) and NanoFolder).

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Performance of Carnac(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 47
Total TN 24560
Total FP 13
Total FP CONTRA 1
Total FP INCONS 10
Total FP COMP 2
Total FN 101
Total Scores
MCC 0.506
Average MCC ± 95% Confidence Intervals 0.373 ± 0.454
Sensitivity 0.318
Positive Predictive Value 0.810
Nr of predictions 4

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 24466
Total FP 114
Total FP CONTRA 15
Total FP INCONS 89
Total FP COMP 10
Total FN 100
Total Scores
MCC 0.316
Average MCC ± 95% Confidence Intervals 0.345 ± 0.403
Sensitivity 0.324
Positive Predictive Value 0.316
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.