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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & PETfold_pre2.0(20) [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) PETfold_pre2.0(20)
MCC 0.650 > 0.625
Average MCC ± 95% Confidence Intervals 0.613 ± 0.256 > 0.581 ± 0.300
Sensitivity 0.473 < 0.497
Positive Predictive Value 0.898 > 0.790
Total TP 79 < 83
Total TN 25805 > 25788
Total FP 13 < 33
Total FP CONTRA 1 > 0
Total FP INCONS 8 < 22
Total FP COMP 4 < 11
Total FN 88 > 84
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and PETfold_pre2.0(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and PETfold_pre2.0(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and PETfold_pre2.0(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and PETfold_pre2.0(20)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 79
Total TN 25805
Total FP 13
Total FP CONTRA 1
Total FP INCONS 8
Total FP COMP 4
Total FN 88
Total Scores
MCC 0.650
Average MCC ± 95% Confidence Intervals 0.613 ± 0.256
Sensitivity 0.473
Positive Predictive Value 0.898
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.76 0.63 0.92 34 7103 4 0 3 1 20
4A1C_2 0.26 0.15 0.45 5 11770 8 1 5 2 28
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12

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Performance of PETfold_pre2.0(20) - scored lower in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 83
Total TN 25788
Total FP 33
Total FP CONTRA 0
Total FP INCONS 22
Total FP COMP 11
Total FN 84
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.581 ± 0.300
Sensitivity 0.497
Positive Predictive Value 0.790
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.82 0.69 0.97 37 7102 1 0 1 0 17
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.61 0.42 0.89 8 1266 1 0 1 0 11
4ENC_A 0.55 0.42 0.73 8 1315 3 0 3 0 11

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.