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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

  4. Performance of RNASLOpt - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidAlifold(20) & RNASLOpt [.zip] - may take several seconds...


Overview

Metric CentroidAlifold(20) RNASLOpt
MCC 0.650 > 0.467
Average MCC ± 95% Confidence Intervals 0.613 ± 0.256 > 0.514 ± 0.309
Sensitivity 0.473 > 0.383
Positive Predictive Value 0.898 > 0.577
Total TP 79 > 64
Total TN 25805 > 25782
Total FP 13 < 53
Total FP CONTRA 1 < 11
Total FP INCONS 8 < 36
Total FP COMP 4 < 6
Total FN 88 < 103
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidAlifold(20) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and RNASLOpt).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and RNASLOpt).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP 79
Total TN 25805
Total FP 13
Total FP CONTRA 1
Total FP INCONS 8
Total FP COMP 4
Total FN 88
Total Scores
MCC 0.650
Average MCC ± 95% Confidence Intervals 0.613 ± 0.256
Sensitivity 0.473
Positive Predictive Value 0.898
Nr of predictions 5

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.76 0.63 0.92 34 7103 4 0 3 1 20
4A1C_2 0.26 0.15 0.45 5 11770 8 1 5 2 28
4AOB_A 0.75 0.57 1.00 24 4347 1 0 0 1 18
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.60 0.37 1.00 7 1319 0 0 0 0 12

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP 64
Total TN 25782
Total FP 53
Total FP CONTRA 11
Total FP INCONS 36
Total FP COMP 6
Total FN 103
Total Scores
MCC 0.467
Average MCC ± 95% Confidence Intervals 0.514 ± 0.309
Sensitivity 0.383
Positive Predictive Value 0.577
Nr of predictions 5

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.23 0.24 0.22 8 11744 35 8 21 6 25
4AOB_A 0.26 0.19 0.38 8 4350 13 2 11 0 34
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.