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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidFold Multilign(seed)
MCC 0.573 > 0.538
Average MCC ± 95% Confidence Intervals 0.570 ± 0.224 > 0.478 ± 0.538
Sensitivity 0.442 > 0.420
Positive Predictive Value 0.753 > 0.699
Total TP 61 > 58
Total TN 11957 > 11955
Total FP 21 < 26
Total FP CONTRA 3 > 2
Total FP INCONS 17 < 23
Total FP COMP 1 = 1
Total FN 77 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidFold and Multilign(seed)).

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Performance of CentroidFold - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP 61
Total TN 11957
Total FP 21
Total FP CONTRA 3
Total FP INCONS 17
Total FP COMP 1
Total FN 77
Total Scores
MCC 0.573
Average MCC ± 95% Confidence Intervals 0.570 ± 0.224
Sensitivity 0.442
Positive Predictive Value 0.753
Nr of predictions 4

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.49 0.35 0.70 7 1530 3 1 2 0 13
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
4AOB_A 0.45 0.33 0.61 14 4348 10 1 8 1 28

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.