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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CentroidHomfold‑LAST & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric CentroidHomfold‑LAST Multilign(seed)
MCC 0.583 > 0.538
Average MCC ± 95% Confidence Intervals 0.515 ± 0.559 > 0.478 ± 0.538
Sensitivity 0.420 = 0.420
Positive Predictive Value 0.817 > 0.699
Total TP 58 = 58
Total TN 11967 > 11955
Total FP 14 < 26
Total FP CONTRA 0 < 2
Total FP INCONS 13 < 23
Total FP COMP 1 = 1
Total FN 80 = 80
P-value 0.0

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Performance plots


  1. Comparison of performance of CentroidHomfold-LAST and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidHomfold-LAST and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidHomfold‑LAST and Multilign(seed)).

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Performance of CentroidHomfold‑LAST - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 58
Total TN 11967
Total FP 14
Total FP CONTRA 0
Total FP INCONS 13
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.583
Average MCC ± 95% Confidence Intervals 0.515 ± 0.559
Sensitivity 0.420
Positive Predictive Value 0.817
Nr of predictions 4

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1529 11 0 11 0 20
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.64 0.45 0.90 19 3895 2 0 2 0 23
4AOB_A 0.71 0.50 1.00 21 4350 1 0 0 1 21

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.