CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Carnac(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Carnac(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Carnac(20)
MCC 0.579 > 0.476
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278 > 0.299 ± 0.370
Sensitivity 0.443 > 0.281
Positive Predictive Value 0.763 < 0.810
Total TP 74 > 47
Total TN 25796 < 25835
Total FP 37 > 13
Total FP CONTRA 2 > 1
Total FP INCONS 21 > 10
Total FP COMP 14 > 2
Total FN 93 < 120
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Carnac(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Carnac(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Carnac(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 25796
Total FP 37
Total FP CONTRA 2
Total FP INCONS 21
Total FP COMP 14
Total FN 93
Total Scores
MCC 0.579
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278
Sensitivity 0.443
Positive Predictive Value 0.763
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of Carnac(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(20)

Total Base Pair Counts
Total TP 47
Total TN 25835
Total FP 13
Total FP CONTRA 1
Total FP INCONS 10
Total FP COMP 2
Total FN 120
Total Scores
MCC 0.476
Average MCC ± 95% Confidence Intervals 0.299 ± 0.370
Sensitivity 0.281
Positive Predictive Value 0.810
Nr of predictions 5

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2. Individual counts for Carnac(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.67 0.52 0.88 28 7108 4 0 4 0 26
4A1C_2 0.33 0.15 0.71 5 11774 3 0 2 1 28
4AOB_A 0.49 0.33 0.74 14 4352 6 1 4 1 28
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.