CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	ContextFold		Cylofold
MCC	0.608	>	0.492
Average MCC ± 95% Confidence Intervals	0.551 ± 0.172	>	0.474 ± 0.169
Sensitivity	0.492	>	0.422
Positive Predictive Value	0.759	>	0.584
Total TP	154	>	132
Total TN	32953	>	32930
Total FP	54	<	97
Total FP CONTRA	5	<	9
Total FP INCONS	44	<	85
Total FP COMP	5	>	3
Total FN	159	<	181
P-value	2.08252958266e-08

Comparison of performance of ContextFold and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Cylofold).
Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Cylofold).

Total Scores
MCC	0.608
Average MCC ± 95% Confidence Intervals	0.551 ± 0.172
Sensitivity	0.492
Positive Predictive Value	0.759
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.55	0.50	0.63	10	1524	6	0	6	0	10
2LKR_A	-	0.65	0.56	0.76	22	6076	9	0	7	2	17
3J0L_a	-	0.71	0.56	0.90	9	1118	1	0	1	0	7
3J0L_7	-	-0.01	0.00	0.00	0	1212	13	0	13	0	17
3J0L_g	-	-0.01	0.00	0.00	0	462	3	1	2	0	4
3J0L_2	-	0.64	0.61	0.69	20	6187	11	2	7	2	13
3J16_L	tRNA links to Rfam database...	0.75	0.57	1.00	17	2758	0	0	0	0	13
3U4M_B	-	0.75	0.57	1.00	21	3139	0	0	0	0	16
3UZL_B	tRNA links to Rfam database...	0.72	0.54	0.95	20	3549	1	0	1	0	17
4AOB_A	SAM links to Rfam database...	0.52	0.40	0.68	17	4346	9	1	7	1	25
4ENB_A	crcB links to Rfam database...	0.69	0.47	1.00	9	1266	0	0	0	0	10
4ENC_A	crcB links to Rfam database...	0.65	0.47	0.90	9	1316	1	1	0	0	10

Total Scores
MCC	0.492
Average MCC ± 95% Confidence Intervals	0.474 ± 0.169
Sensitivity	0.422
Positive Predictive Value	0.584
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
2LC8_A	GP_knot1 links to Rfam database...	0.61	0.55	0.69	11	1524	5	0	5	0	9
2LKR_A	-	0.50	0.44	0.59	17	6076	12	2	10	0	22
3J0L_a	-	0.22	0.19	0.27	3	1117	8	1	7	0	13
3J0L_7	-	0.30	0.29	0.33	5	1210	10	0	10	0	12
3J0L_g	-	-0.01	0.00	0.00	0	461	4	1	3	0	4
3J0L_2	-	0.39	0.36	0.43	12	6188	18	2	14	2	21
3J16_L	tRNA links to Rfam database...	0.75	0.57	1.00	17	2758	0	0	0	0	13
3U4M_B	-	0.38	0.32	0.46	12	3134	14	0	14	0	25
3UZL_B	tRNA links to Rfam database...	0.45	0.38	0.54	14	3544	12	1	11	0	23
4AOB_A	SAM links to Rfam database...	0.35	0.26	0.48	11	4348	13	1	11	1	31
4ENB_A	crcB links to Rfam database...	0.89	0.79	1.00	15	1260	0	0	0	0	4
4ENC_A	crcB links to Rfam database...	0.86	0.79	0.94	15	1310	1	1	0	0	4

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.