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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Mastr(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Mastr(20) [.zip] - may take several seconds...


Overview

Metric ContextFold Mastr(20)
MCC 0.579 > 0.488
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278 > 0.399 ± 0.320
Sensitivity 0.443 > 0.305
Positive Predictive Value 0.763 < 0.785
Total TP 74 > 51
Total TN 25796 < 25828
Total FP 37 > 16
Total FP CONTRA 2 > 0
Total FP INCONS 21 > 14
Total FP COMP 14 > 2
Total FN 93 < 116
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Mastr(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Mastr(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Mastr(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Mastr(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 25796
Total FP 37
Total FP CONTRA 2
Total FP INCONS 21
Total FP COMP 14
Total FN 93
Total Scores
MCC 0.579
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278
Sensitivity 0.443
Positive Predictive Value 0.763
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of Mastr(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(20)

Total Base Pair Counts
Total TP 51
Total TN 25828
Total FP 16
Total FP CONTRA 0
Total FP INCONS 14
Total FP COMP 2
Total FN 116
Total Scores
MCC 0.488
Average MCC ± 95% Confidence Intervals 0.399 ± 0.320
Sensitivity 0.305
Positive Predictive Value 0.785
Nr of predictions 5

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2. Individual counts for Mastr(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.70 0.59 0.84 32 7102 7 0 6 1 22
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.39 0.26 0.58 11 4352 9 0 8 1 31
4ENB_A 0.39 0.16 1.00 3 1272 0 0 0 0 16
4ENC_A 0.51 0.26 1.00 5 1321 0 0 0 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.