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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric ContextFold Multilign(seed)
MCC 0.532 > 0.403
Average MCC ± 95% Confidence Intervals 0.538 ± 0.208 > 0.299 ± 3.931
Sensitivity 0.435 > 0.306
Positive Predictive Value 0.659 > 0.543
Total TP 27 > 19
Total TN 5870 < 5876
Total FP 15 < 17
Total FP CONTRA 1 = 1
Total FP INCONS 13 < 15
Total FP COMP 1 = 1
Total FN 35 < 43
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and Multilign(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 27
Total TN 5870
Total FP 15
Total FP CONTRA 1
Total FP INCONS 13
Total FP COMP 1
Total FN 35
Total Scores
MCC 0.532
Average MCC ± 95% Confidence Intervals 0.538 ± 0.208
Sensitivity 0.435
Positive Predictive Value 0.659
Nr of predictions 2

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.55 0.50 0.63 10 1524 6 0 6 0 10
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 19
Total TN 5876
Total FP 17
Total FP CONTRA 1
Total FP INCONS 15
Total FP COMP 1
Total FN 43
Total Scores
MCC 0.403
Average MCC ± 95% Confidence Intervals 0.299 ± 3.931
Sensitivity 0.306
Positive Predictive Value 0.543
Nr of predictions 2

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.