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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of ContextFold - scored higher in this pairwise comparison

  4. Performance of TurboFold(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for ContextFold & TurboFold(20) [.zip] - may take several seconds...


Overview

Metric ContextFold TurboFold(20)
MCC 0.579 > 0.542
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278 > 0.552 ± 0.270
Sensitivity 0.443 > 0.425
Positive Predictive Value 0.763 > 0.696
Total TP 74 > 71
Total TN 25796 > 25791
Total FP 37 < 41
Total FP CONTRA 2 = 2
Total FP INCONS 21 < 29
Total FP COMP 14 > 10
Total FN 93 < 96
P-value 0.0

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Performance plots


  1. Comparison of performance of ContextFold and TurboFold(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and TurboFold(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and TurboFold(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and TurboFold(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP 74
Total TN 25796
Total FP 37
Total FP CONTRA 2
Total FP INCONS 21
Total FP COMP 14
Total FN 93
Total Scores
MCC 0.579
Average MCC ± 95% Confidence Intervals 0.568 ± 0.278
Sensitivity 0.443
Positive Predictive Value 0.763
Nr of predictions 5

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.78 0.63 0.97 34 7105 1 0 1 0 20
4A1C_2 0.20 0.15 0.28 5 11763 26 0 13 13 28
4AOB_A 0.52 0.40 0.68 17 4346 9 1 7 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of TurboFold(20) - scored lower in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 71
Total TN 25791
Total FP 41
Total FP CONTRA 2
Total FP INCONS 29
Total FP COMP 10
Total FN 96
Total Scores
MCC 0.542
Average MCC ± 95% Confidence Intervals 0.552 ± 0.270
Sensitivity 0.425
Positive Predictive Value 0.696
Nr of predictions 5

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.18 0.15 0.21 5 11757 28 0 19 9 28
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.