CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Contrafold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Contrafold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Contrafold Multilign(seed)
MCC 0.552 > 0.538
Average MCC ± 95% Confidence Intervals 0.546 ± 0.215 > 0.478 ± 0.538
Sensitivity 0.449 > 0.420
Positive Predictive Value 0.689 < 0.699
Total TP 62 > 58
Total TN 11948 < 11955
Total FP 29 > 26
Total FP CONTRA 6 > 2
Total FP INCONS 22 < 23
Total FP COMP 1 = 1
Total FN 76 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of Contrafold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Contrafold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Contrafold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Contrafold and Multilign(seed)).

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Performance of Contrafold - scored higher in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP 62
Total TN 11948
Total FP 29
Total FP CONTRA 6
Total FP INCONS 22
Total FP COMP 1
Total FN 76
Total Scores
MCC 0.552
Average MCC ± 95% Confidence Intervals 0.546 ± 0.215
Sensitivity 0.449
Positive Predictive Value 0.689
Nr of predictions 4

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.45 0.35 0.58 7 1528 5 2 3 0 13
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 2 7 0 22
4AOB_A 0.44 0.36 0.56 15 4344 13 1 11 1 27

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.