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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & Multilign(20) [.zip] - may take several seconds...


Overview

Metric Cylofold Multilign(20)
MCC 0.653 > 0.582
Average MCC ± 95% Confidence Intervals 0.692 ± 0.207 > 0.573 ± 0.154
Sensitivity 0.536 > 0.470
Positive Predictive Value 0.803 > 0.729
Total TP 98 > 86
Total TN 15980 < 15984
Total FP 27 < 35
Total FP CONTRA 2 < 4
Total FP INCONS 22 < 28
Total FP COMP 3 = 3
Total FN 85 < 97
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and Multilign(20)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 98
Total TN 15980
Total FP 27
Total FP CONTRA 2
Total FP INCONS 22
Total FP COMP 3
Total FN 85
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.692 ± 0.207
Sensitivity 0.536
Positive Predictive Value 0.803
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 86
Total TN 15984
Total FP 35
Total FP CONTRA 4
Total FP INCONS 28
Total FP COMP 3
Total FN 97
Total Scores
MCC 0.582
Average MCC ± 95% Confidence Intervals 0.573 ± 0.154
Sensitivity 0.470
Positive Predictive Value 0.729
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.63 0.56 0.71 15 2982 8 0 6 2 12
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26
4ENB_A 0.34 0.26 0.45 5 1264 6 1 5 0 14
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.