CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Cylofold - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Cylofold & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric Cylofold RNASampler(seed)
MCC 0.571 > 0.510
Average MCC ± 95% Confidence Intervals 0.588 ± 0.270 > 0.451 ± 0.529
Sensitivity 0.489 > 0.366
Positive Predictive Value 0.674 < 0.716
Total TP 64 > 48
Total TN 19975 < 20003
Total FP 40 > 23
Total FP CONTRA 5 > 2
Total FP INCONS 26 > 17
Total FP COMP 9 > 4
Total FN 67 < 83
P-value 0.0

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Performance plots


  1. Comparison of performance of Cylofold and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Cylofold and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Cylofold and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Cylofold and RNASampler(seed)).

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Performance of Cylofold - scored higher in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 64
Total TN 19975
Total FP 40
Total FP CONTRA 5
Total FP INCONS 26
Total FP COMP 9
Total FN 67
Total Scores
MCC 0.571
Average MCC ± 95% Confidence Intervals 0.588 ± 0.270
Sensitivity 0.489
Positive Predictive Value 0.674
Nr of predictions 4

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
3O58_3 0.36 0.34 0.38 12 12371 29 5 15 9 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 48
Total TN 20003
Total FP 23
Total FP CONTRA 2
Total FP INCONS 17
Total FP COMP 4
Total FN 83
Total Scores
MCC 0.510
Average MCC ± 95% Confidence Intervals 0.451 ± 0.529
Sensitivity 0.366
Positive Predictive Value 0.716
Nr of predictions 4

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3O58_3 0.45 0.34 0.60 12 12383 12 2 6 4 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.