CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Fold - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Fold & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric Fold Mastr(seed)
MCC 0.560 > 0.000
Average MCC ± 95% Confidence Intervals 0.579 ± 0.112 > 0.000 ± 0.000
Sensitivity 0.504 > 0.000
Positive Predictive Value 0.627 > 0.000
Total TP 468 > 0
Total TN 229568 < 230315
Total FP 321 > 0
Total FP CONTRA 47 > 0
Total FP INCONS 232 > 0
Total FP COMP 42 > 0
Total FN 461 < 929
P-value 5.10776592382e-08

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Performance plots


  1. Comparison of performance of Fold and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Fold and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Fold and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Fold and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Fold and Mastr(seed)).

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Performance of Fold - scored higher in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP 468
Total TN 229568
Total FP 321
Total FP CONTRA 47
Total FP INCONS 232
Total FP COMP 42
Total FN 461
Total Scores
MCC 0.560
Average MCC ± 95% Confidence Intervals 0.579 ± 0.112
Sensitivity 0.504
Positive Predictive Value 0.627
Nr of predictions 22

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2. Individual counts for Fold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.94 0.89 1.00 16 845 0 0 0 0 2
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
2WWQ_V 0.76 0.64 0.90 18 2906 3 0 2 1 10
2XQD_Y 0.88 0.78 1.00 21 2829 0 0 0 0 6
3AKZ_H 0.84 0.75 0.95 21 2679 1 1 0 0 7
3AMU_B 0.64 0.59 0.70 16 2980 9 0 7 2 11
3IYQ_A 0.29 0.31 0.27 29 60618 83 20 59 4 65
3IZ4_A 0.53 0.46 0.61 61 70776 44 5 34 5 71
3IZF_C 0.70 0.59 0.82 32 6864 7 1 6 0 22
3J16_L 0.63 0.53 0.76 16 2754 5 0 5 0 14
3NPB_A 0.70 0.61 0.80 28 6986 10 1 6 3 18
3O58_3 0.29 0.31 0.28 11 12363 41 3 26 12 24
3O58_2 0.71 0.71 0.71 27 7222 12 3 8 1 11
3PDR_A 0.77 0.64 0.94 46 12831 5 0 3 2 26
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
3UZL_B 0.77 0.62 0.96 23 3546 1 0 1 0 14
4A1C_2 0.14 0.15 0.14 5 11744 43 5 27 11 28
4A1C_3 0.68 0.57 0.82 31 7102 7 1 6 0 23
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.32 0.26 0.42 5 1263 7 1 6 0 14
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 0
Total TN 230315
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 929
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 22

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2KX8_A 0.00 0.00 0.00 0 861 0 0 0 0 18
2LC8_A 0.00 0.00 0.00 0 1540 0 0 0 0 20
2WWQ_V 0.00 0.00 0.00 0 2926 0 0 0 0 28
2XQD_Y 0.00 0.00 0.00 0 2850 0 0 0 0 27
3AKZ_H 0.00 0.00 0.00 0 2701 0 0 0 0 28
3AMU_B 0.00 0.00 0.00 0 3003 0 0 0 0 27
3IYQ_A 0.00 0.00 0.00 0 60726 0 0 0 0 94
3IZ4_A 0.00 0.00 0.00 0 70876 0 0 0 0 132
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3J16_L 0.00 0.00 0.00 0 2775 0 0 0 0 30
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
3UZL_B 0.00 0.00 0.00 0 3570 0 0 0 0 37
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.