CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of RNASampler(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & RNASampler(seed) [.zip] - may take several seconds...


Overview

Metric IPknot RNASampler(seed)
MCC 0.493 > 0.471
Average MCC ± 95% Confidence Intervals 0.487 ± 0.413 > 0.415 ± 0.540
Sensitivity 0.395 > 0.341
Positive Predictive Value 0.622 < 0.657
Total TP 51 > 44
Total TN 19366 < 19381
Total FP 36 > 31
Total FP CONTRA 5 > 0
Total FP INCONS 26 > 23
Total FP COMP 5 < 8
Total FN 78 < 85
P-value 0.0

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Performance plots


  1. Comparison of performance of IPknot and RNASampler(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and RNASampler(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and RNASampler(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 51
Total TN 19366
Total FP 36
Total FP CONTRA 5
Total FP INCONS 26
Total FP COMP 5
Total FN 78
Total Scores
MCC 0.493
Average MCC ± 95% Confidence Intervals 0.487 ± 0.413
Sensitivity 0.395
Positive Predictive Value 0.622
Nr of predictions 4

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.40 0.30 0.55 6 1529 5 1 4 0 14
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.61 0.48 0.80 20 3891 5 0 5 0 22
4A1C_2 0.17 0.15 0.19 5 11755 26 4 17 5 28

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Performance of RNASampler(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 44
Total TN 19381
Total FP 31
Total FP CONTRA 0
Total FP INCONS 23
Total FP COMP 8
Total FN 85
Total Scores
MCC 0.471
Average MCC ± 95% Confidence Intervals 0.415 ± 0.540
Sensitivity 0.341
Positive Predictive Value 0.657
Nr of predictions 4

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.