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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) Multilign(seed)
MCC 0.577 > 0.538
Average MCC ± 95% Confidence Intervals 0.502 ± 0.545 > 0.478 ± 0.538
Sensitivity 0.464 > 0.420
Positive Predictive Value 0.727 > 0.699
Total TP 64 > 58
Total TN 11950 < 11955
Total FP 27 > 26
Total FP CONTRA 1 < 2
Total FP INCONS 23 = 23
Total FP COMP 3 > 1
Total FN 74 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of MXScarna(seed) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Multilign(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 64
Total TN 11950
Total FP 27
Total FP CONTRA 1
Total FP INCONS 23
Total FP COMP 3
Total FN 74
Total Scores
MCC 0.577
Average MCC ± 95% Confidence Intervals 0.502 ± 0.545
Sensitivity 0.464
Positive Predictive Value 0.727
Nr of predictions 4

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 12 0 10 2 20
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.63 0.55 0.74 23 3885 8 1 7 0 19
4AOB_A 0.66 0.55 0.79 23 4342 7 0 6 1 19

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.