CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MaxExpect - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MaxExpect & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric MaxExpect Carnac(seed)
MCC 0.595 > 0.077
Average MCC ± 95% Confidence Intervals 0.572 ± 0.123 > 0.025 ± 0.052
Sensitivity 0.517 > 0.006
Positive Predictive Value 0.689 < 1.000
Total TP 348 > 4
Total TN 107298 < 107799
Total FP 211 > 0
Total FP CONTRA 21 > 0
Total FP INCONS 136 > 0
Total FP COMP 54 > 0
Total FN 325 < 669
P-value 3.36130997681e-08

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Performance plots


  1. Comparison of performance of MaxExpect and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and Carnac(seed)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP 348
Total TN 107298
Total FP 211
Total FP CONTRA 21
Total FP INCONS 136
Total FP COMP 54
Total FN 325
Total Scores
MCC 0.595
Average MCC ± 95% Confidence Intervals 0.572 ± 0.123
Sensitivity 0.517
Positive Predictive Value 0.689
Nr of predictions 18

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3GX2_A 0.77 0.63 0.96 25 4345 2 0 1 1 15
3IVN_B 0.78 0.61 1.00 19 2327 0 0 0 0 12
3IZF_C 0.71 0.61 0.83 33 6863 7 1 6 0 21
3JYX_3 0.64 0.63 0.65 17 6302 19 1 8 10 10
3JYX_4 0.31 0.30 0.31 10 12214 34 4 18 12 23
3LA5_A 0.78 0.62 1.00 21 2464 0 0 0 0 13
3NPB_A 0.71 0.61 0.82 28 6987 9 0 6 3 18
3O58_3 0.35 0.34 0.35 12 12369 35 2 20 13 23
3O58_2 0.75 0.76 0.74 29 7221 11 3 7 1 9
3PDR_A 0.76 0.63 0.94 45 12832 5 0 3 2 27
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.58 0.48 0.71 20 3888 8 1 7 0 22
4A1C_2 0.14 0.15 0.14 5 11746 41 4 26 11 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.31 0.26 0.38 5 1313 8 1 7 0 14

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 4
Total TN 107799
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 669
Total Scores
MCC 0.077
Average MCC ± 95% Confidence Intervals 0.025 ± 0.052
Sensitivity 0.006
Positive Predictive Value 1.000
Nr of predictions 18

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
3GX2_A 0.00 0.00 0.00 0 4371 0 0 0 0 40
3IVN_B 0.00 0.00 0.00 0 2346 0 0 0 0 31
3IZF_C 0.00 0.00 0.00 0 6903 0 0 0 0 54
3JYX_3 0.00 0.00 0.00 0 6328 0 0 0 0 27
3JYX_4 0.00 0.00 0.00 0 12246 0 0 0 0 33
3LA5_A 0.00 0.00 0.00 0 2485 0 0 0 0 34
3NPB_A 0.00 0.00 0.00 0 7021 0 0 0 0 46
3O58_3 0.00 0.00 0.00 0 12403 0 0 0 0 35
3O58_2 0.00 0.00 0.00 0 7260 0 0 0 0 38
3PDR_A 0.00 0.00 0.00 0 12880 0 0 0 0 72
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENB_A 0.00 0.00 0.00 0 1275 0 0 0 0 19
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.