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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of McQFold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for McQFold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric McQFold Multilign(seed)
MCC 0.621 > 0.538
Average MCC ± 95% Confidence Intervals 0.627 ± 0.243 > 0.478 ± 0.538
Sensitivity 0.507 > 0.420
Positive Predictive Value 0.769 > 0.699
Total TP 70 > 58
Total TN 11947 < 11955
Total FP 22 < 26
Total FP CONTRA 1 < 2
Total FP INCONS 20 < 23
Total FP COMP 1 = 1
Total FN 68 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of McQFold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and Multilign(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP 70
Total TN 11947
Total FP 22
Total FP CONTRA 1
Total FP INCONS 20
Total FP COMP 1
Total FN 68
Total Scores
MCC 0.621
Average MCC ± 95% Confidence Intervals 0.627 ± 0.243
Sensitivity 0.507
Positive Predictive Value 0.769
Nr of predictions 4

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.71 0.60 0.86 25 3887 4 0 4 0 17
4AOB_A 0.42 0.33 0.54 14 4345 13 1 11 1 28

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.