CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & RDfolder [.zip] - may take several seconds...


Overview

Metric Multilign(20) RDfolder
MCC 0.582 > 0.407
Average MCC ± 95% Confidence Intervals 0.573 ± 0.154 > 0.407 ± 0.209
Sensitivity 0.470 > 0.295
Positive Predictive Value 0.729 > 0.574
Total TP 86 > 54
Total TN 15984 < 16008
Total FP 35 < 43
Total FP CONTRA 4 > 3
Total FP INCONS 28 < 37
Total FP COMP 3 = 3
Total FN 97 < 129
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and RDfolder).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 86
Total TN 15984
Total FP 35
Total FP CONTRA 4
Total FP INCONS 28
Total FP COMP 3
Total FN 97
Total Scores
MCC 0.582
Average MCC ± 95% Confidence Intervals 0.573 ± 0.154
Sensitivity 0.470
Positive Predictive Value 0.729
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.63 0.56 0.71 15 2982 8 0 6 2 12
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26
4ENB_A 0.34 0.26 0.45 5 1264 6 1 5 0 14
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 54
Total TN 16008
Total FP 43
Total FP CONTRA 3
Total FP INCONS 37
Total FP COMP 3
Total FN 129
Total Scores
MCC 0.407
Average MCC ± 95% Confidence Intervals 0.407 ± 0.209
Sensitivity 0.295
Positive Predictive Value 0.574
Nr of predictions 6

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.18 0.15 0.22 4 2985 16 2 12 2 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.30 0.17 0.54 7 3903 6 0 6 0 35
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.43 0.32 0.60 6 1265 4 0 4 0 13
4ENC_A 0.43 0.32 0.60 6 1316 4 0 4 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.