CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) Carnac(seed)
MCC 0.538 > 0.169
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538 > 0.111 ± 0.354
Sensitivity 0.420 > 0.029
Positive Predictive Value 0.699 < 1.000
Total TP 58 > 4
Total TN 11955 < 12034
Total FP 26 > 0
Total FP CONTRA 2 > 0
Total FP INCONS 23 > 0
Total FP COMP 1 > 0
Total FN 80 < 134
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and Carnac(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and Carnac(seed)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 4
Total TN 12034
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 134
Total Scores
MCC 0.169
Average MCC ± 95% Confidence Intervals 0.111 ± 0.354
Sensitivity 0.029
Positive Predictive Value 1.000
Nr of predictions 4

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.