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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of PPfold(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & PPfold(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(seed) PPfold(seed)
MCC 0.538 > 0.179
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538 > 0.118 ± 0.374
Sensitivity 0.420 > 0.043
Positive Predictive Value 0.699 < 0.750
Total TP 58 > 6
Total TN 11955 < 12030
Total FP 26 > 2
Total FP CONTRA 2 > 0
Total FP INCONS 23 > 2
Total FP COMP 1 > 0
Total FN 80 < 132
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and PPfold(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and PPfold(seed)).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP 6
Total TN 12030
Total FP 2
Total FP CONTRA 0
Total FP INCONS 2
Total FP COMP 0
Total FN 132
Total Scores
MCC 0.179
Average MCC ± 95% Confidence Intervals 0.118 ± 0.374
Sensitivity 0.043
Positive Predictive Value 0.750
Nr of predictions 4

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.47 0.30 0.75 6 1532 2 0 2 0 14
3RKF_A 0.00 0.00 0.00 0 2211 0 0 0 0 34
3SD1_A 0.00 0.00 0.00 0 3916 0 0 0 0 42
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.