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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(seed) - scored higher in this pairwise comparison

  4. Performance of UNAFold - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(seed) & UNAFold [.zip] - may take several seconds...


Overview

Metric Multilign(seed) UNAFold
MCC 0.538 > 0.525
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538 > 0.473 ± 0.542
Sensitivity 0.420 < 0.428
Positive Predictive Value 0.699 > 0.656
Total TP 58 < 59
Total TN 11955 > 11948
Total FP 26 < 32
Total FP CONTRA 2 < 5
Total FP INCONS 23 < 26
Total FP COMP 1 = 1
Total FN 80 > 79
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(seed) and UNAFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(seed) and UNAFold).

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Performance of Multilign(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 59
Total TN 11948
Total FP 32
Total FP CONTRA 5
Total FP INCONS 26
Total FP COMP 1
Total FN 79
Total Scores
MCC 0.525
Average MCC ± 95% Confidence Intervals 0.473 ± 0.542
Sensitivity 0.428
Positive Predictive Value 0.656
Nr of predictions 4

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.