CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric NanoFolder Carnac(seed)
MCC 0.341 > 0.154
Average MCC ± 95% Confidence Intervals 0.379 ± 0.289 > 0.089 ± 0.247
Sensitivity 0.351 > 0.024
Positive Predictive Value 0.339 < 1.000
Total TP 59 > 4
Total TN 25984 < 26154
Total FP 125 > 0
Total FP CONTRA 15 > 0
Total FP INCONS 100 > 0
Total FP COMP 10 > 0
Total FN 109 < 164
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and Carnac(seed)).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 59
Total TN 25984
Total FP 125
Total FP CONTRA 15
Total FP INCONS 100
Total FP COMP 10
Total FN 109
Total Scores
MCC 0.341
Average MCC ± 95% Confidence Intervals 0.379 ± 0.289
Sensitivity 0.351
Positive Predictive Value 0.339
Nr of predictions 5

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.55 0.50 11 1518 11 0 11 0 9
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 4
Total TN 26154
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 164
Total Scores
MCC 0.154
Average MCC ± 95% Confidence Intervals 0.089 ± 0.247
Sensitivity 0.024
Positive Predictive Value 1.000
Nr of predictions 5

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.44 0.20 1.00 4 1536 0 0 0 0 16
4A1C_3 0.00 0.00 0.00 0 7140 0 0 0 0 54
4A1C_2 0.00 0.00 0.00 0 11781 0 0 0 0 33
4AOB_A 0.00 0.00 0.00 0 4371 0 0 0 0 42
4ENC_A 0.00 0.00 0.00 0 1326 0 0 0 0 19

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.