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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of NanoFolder - scored higher in this pairwise comparison

  4. Performance of RDfolder - scored lower in this pairwise comparison

  5. Compile and download dataset for NanoFolder & RDfolder [.zip] - may take several seconds...


Overview

Metric NanoFolder RDfolder
MCC 0.417 > 0.257
Average MCC ± 95% Confidence Intervals 0.444 ± 0.190 > 0.248 ± 0.306
Sensitivity 0.405 > 0.198
Positive Predictive Value 0.441 > 0.349
Total TP 45 > 22
Total TN 9910 < 9949
Total FP 59 > 42
Total FP CONTRA 4 > 3
Total FP INCONS 53 > 38
Total FP COMP 2 > 1
Total FN 66 < 89
P-value 0.0

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Performance plots


  1. Comparison of performance of NanoFolder and RDfolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for NanoFolder and RDfolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for NanoFolder and RDfolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for NanoFolder and RDfolder).

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Performance of NanoFolder - scored higher in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 45
Total TN 9910
Total FP 59
Total FP CONTRA 4
Total FP INCONS 53
Total FP COMP 2
Total FN 66
Total Scores
MCC 0.417
Average MCC ± 95% Confidence Intervals 0.444 ± 0.190
Sensitivity 0.405
Positive Predictive Value 0.441
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.52 0.55 0.50 11 1518 11 0 11 0 9
3J16_L 0.36 0.37 0.37 11 2745 19 3 16 0 19
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Performance of RDfolder - scored lower in this pairwise comparison

1. Total counts & total scores for RDfolder

Total Base Pair Counts
Total TP 22
Total TN 9949
Total FP 42
Total FP CONTRA 3
Total FP INCONS 38
Total FP COMP 1
Total FN 89
Total Scores
MCC 0.257
Average MCC ± 95% Confidence Intervals 0.248 ± 0.306
Sensitivity 0.198
Positive Predictive Value 0.349
Nr of predictions 4

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2. Individual counts for RDfolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1526 14 2 12 0 20
3J16_L 0.22 0.17 0.31 5 2759 11 0 11 0 25
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENC_A 0.43 0.32 0.60 6 1316 4 0 4 0 13

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.