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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

  4. Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

  5. Compile and download dataset for PETfold_pre2.0(20) & CentroidHomfold‑LAST [.zip] - may take several seconds...


Overview

Metric PETfold_pre2.0(20) CentroidHomfold‑LAST
MCC 0.625 > 0.581
Average MCC ± 95% Confidence Intervals 0.581 ± 0.300 < 0.613 ± 0.316
Sensitivity 0.497 > 0.467
Positive Predictive Value 0.790 > 0.729
Total TP 83 > 78
Total TN 25788 > 25786
Total FP 33 < 36
Total FP CONTRA 0 < 5
Total FP INCONS 22 < 24
Total FP COMP 11 > 7
Total FN 84 < 89
P-value 0.0

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Performance plots


  1. Comparison of performance of PETfold_pre2.0(20) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(20) and CentroidHomfold‑LAST).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(20) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(20) and CentroidHomfold‑LAST).

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Performance of PETfold_pre2.0(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(20)

Total Base Pair Counts
Total TP 83
Total TN 25788
Total FP 33
Total FP CONTRA 0
Total FP INCONS 22
Total FP COMP 11
Total FN 84
Total Scores
MCC 0.625
Average MCC ± 95% Confidence Intervals 0.581 ± 0.300
Sensitivity 0.497
Positive Predictive Value 0.790
Nr of predictions 5

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2. Individual counts for PETfold_pre2.0(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.82 0.69 0.97 37 7102 1 0 1 0 17
4A1C_2 0.19 0.15 0.25 5 11761 25 0 15 10 28
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.61 0.42 0.89 8 1266 1 0 1 0 11
4ENC_A 0.55 0.42 0.73 8 1315 3 0 3 0 11

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Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 78
Total TN 25786
Total FP 36
Total FP CONTRA 5
Total FP INCONS 24
Total FP COMP 7
Total FN 89
Total Scores
MCC 0.581
Average MCC ± 95% Confidence Intervals 0.613 ± 0.316
Sensitivity 0.467
Positive Predictive Value 0.729
Nr of predictions 5

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.68 0.56 0.83 30 7104 6 0 6 0 24
4A1C_2 0.16 0.15 0.18 5 11753 29 5 18 6 28
4AOB_A 0.71 0.50 1.00 21 4350 1 0 0 1 21
4ENB_A 0.76 0.58 1.00 11 1264 0 0 0 0 8
4ENC_A 0.76 0.58 1.00 11 1315 0 0 0 0 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.