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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Cylofold - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Cylofold [.zip] - may take several seconds...


Overview

Metric PPfold(20) Cylofold
MCC 0.710 > 0.653
Average MCC ± 95% Confidence Intervals 0.690 ± 0.116 < 0.692 ± 0.207
Sensitivity 0.552 > 0.536
Positive Predictive Value 0.918 > 0.803
Total TP 101 > 98
Total TN 15992 > 15980
Total FP 11 < 27
Total FP CONTRA 0 < 2
Total FP INCONS 9 < 22
Total FP COMP 2 < 3
Total FN 82 < 85
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Cylofold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Cylofold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Cylofold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Cylofold).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 101
Total TN 15992
Total FP 11
Total FP CONTRA 0
Total FP INCONS 9
Total FP COMP 2
Total FN 82
Total Scores
MCC 0.710
Average MCC ± 95% Confidence Intervals 0.690 ± 0.116
Sensitivity 0.552
Positive Predictive Value 0.918
Nr of predictions 6

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.86 0.74 1.00 20 2983 1 0 0 1 7
3RKF_A 0.73 0.56 0.95 19 2191 1 0 1 0 15
3SD1_A 0.68 0.52 0.88 22 3891 3 0 3 0 20
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENB_A 0.56 0.37 0.88 7 1267 1 0 1 0 12
4ENC_A 0.58 0.42 0.80 8 1316 2 0 2 0 11

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Performance of Cylofold - scored lower in this pairwise comparison

1. Total counts & total scores for Cylofold

Total Base Pair Counts
Total TP 98
Total TN 15980
Total FP 27
Total FP CONTRA 2
Total FP INCONS 22
Total FP COMP 3
Total FN 85
Total Scores
MCC 0.653
Average MCC ± 95% Confidence Intervals 0.692 ± 0.207
Sensitivity 0.536
Positive Predictive Value 0.803
Nr of predictions 6

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2. Individual counts for Cylofold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3AMU_B 0.67 0.59 0.76 16 2982 7 0 5 2 11
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.62 0.50 0.78 21 3889 6 0 6 0 21
4AOB_A 0.35 0.26 0.48 11 4348 13 1 11 1 31
4ENB_A 0.89 0.79 1.00 15 1260 0 0 0 0 4
4ENC_A 0.86 0.79 0.94 15 1310 1 1 0 0 4

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.