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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric PPfold(20) Multilign(seed)
MCC 0.714 > 0.631
Average MCC ± 95% Confidence Intervals 0.714 ± 0.083 > 0.641 ± 0.275
Sensitivity 0.559 > 0.492
Positive Predictive Value 0.917 > 0.817
Total TP 66 > 58
Total TN 10426 < 10427
Total FP 7 < 14
Total FP CONTRA 0 < 1
Total FP INCONS 6 < 12
Total FP COMP 1 = 1
Total FN 52 < 60
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and Multilign(seed)).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 66
Total TN 10426
Total FP 7
Total FP CONTRA 0
Total FP INCONS 6
Total FP COMP 1
Total FN 52
Total Scores
MCC 0.714
Average MCC ± 95% Confidence Intervals 0.714 ± 0.083
Sensitivity 0.559
Positive Predictive Value 0.917
Nr of predictions 3

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.73 0.56 0.95 19 2191 1 0 1 0 15
3SD1_A 0.68 0.52 0.88 22 3891 3 0 3 0 20
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 10427
Total FP 14
Total FP CONTRA 1
Total FP INCONS 12
Total FP COMP 1
Total FN 60
Total Scores
MCC 0.631
Average MCC ± 95% Confidence Intervals 0.641 ± 0.275
Sensitivity 0.492
Positive Predictive Value 0.817
Nr of predictions 3

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.