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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of PPfold(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for PPfold(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric PPfold(20) NanoFolder
MCC 0.622 > 0.316
Average MCC ± 95% Confidence Intervals 0.574 ± 0.410 > 0.345 ± 0.403
Sensitivity 0.486 > 0.324
Positive Predictive Value 0.800 > 0.316
Total TP 72 > 48
Total TN 24528 > 24466
Total FP 23 < 114
Total FP CONTRA 0 < 15
Total FP INCONS 18 < 89
Total FP COMP 5 < 10
Total FN 76 < 100
P-value 0.0

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Performance plots


  1. Comparison of performance of PPfold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).

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Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP 72
Total TN 24528
Total FP 23
Total FP CONTRA 0
Total FP INCONS 18
Total FP COMP 5
Total FN 76
Total Scores
MCC 0.622
Average MCC ± 95% Confidence Intervals 0.574 ± 0.410
Sensitivity 0.486
Positive Predictive Value 0.800
Nr of predictions 4

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2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.77 0.63 0.94 34 7104 2 0 2 0 20
4A1C_2 0.21 0.15 0.29 5 11764 16 0 12 4 28
4AOB_A 0.74 0.60 0.93 25 4344 3 0 2 1 17
4ENC_A 0.58 0.42 0.80 8 1316 2 0 2 0 11

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 24466
Total FP 114
Total FP CONTRA 15
Total FP INCONS 89
Total FP COMP 10
Total FN 100
Total Scores
MCC 0.316
Average MCC ± 95% Confidence Intervals 0.345 ± 0.403
Sensitivity 0.324
Positive Predictive Value 0.316
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.