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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(seed) - scored higher in this pairwise comparison

  4. Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(seed) & CentroidHomfold‑LAST [.zip] - may take several seconds...


Overview

Metric RNASampler(seed) CentroidHomfold‑LAST
MCC 0.471 > 0.416
Average MCC ± 95% Confidence Intervals 0.415 ± 0.540 > 0.379 ± 0.570
Sensitivity 0.341 > 0.326
Positive Predictive Value 0.657 > 0.538
Total TP 44 > 42
Total TN 19381 > 19370
Total FP 31 < 42
Total FP CONTRA 0 < 5
Total FP INCONS 23 < 31
Total FP COMP 8 > 6
Total FN 85 < 87
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(seed) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and CentroidHomfold‑LAST).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and CentroidHomfold‑LAST).

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Performance of RNASampler(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 44
Total TN 19381
Total FP 31
Total FP CONTRA 0
Total FP INCONS 23
Total FP COMP 8
Total FN 85
Total Scores
MCC 0.471
Average MCC ± 95% Confidence Intervals 0.415 ± 0.540
Sensitivity 0.341
Positive Predictive Value 0.657
Nr of predictions 4

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP 42
Total TN 19370
Total FP 42
Total FP CONTRA 5
Total FP INCONS 31
Total FP COMP 6
Total FN 87
Total Scores
MCC 0.416
Average MCC ± 95% Confidence Intervals 0.379 ± 0.570
Sensitivity 0.326
Positive Predictive Value 0.538
Nr of predictions 4

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1529 11 0 11 0 20
3RKF_A 0.72 0.53 1.00 18 2193 0 0 0 0 16
3SD1_A 0.64 0.45 0.90 19 3895 2 0 2 0 23
4A1C_2 0.16 0.15 0.18 5 11753 29 5 18 6 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.