CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNASampler(seed) - scored higher in this pairwise comparison

  4. Performance of ProbKnot - scored lower in this pairwise comparison

  5. Compile and download dataset for RNASampler(seed) & ProbKnot [.zip] - may take several seconds...


Overview

Metric RNASampler(seed) ProbKnot
MCC 0.467 > 0.358
Average MCC ± 95% Confidence Intervals 0.423 ± 0.366 > 0.342 ± 0.374
Sensitivity 0.341 < 0.348
Positive Predictive Value 0.644 > 0.375
Total TP 56 < 57
Total TN 31764 > 31699
Total FP 43 < 118
Total FP CONTRA 2 < 16
Total FP INCONS 29 < 79
Total FP COMP 12 < 23
Total FN 108 > 107
P-value 0.0

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Performance plots


  1. Comparison of performance of RNASampler(seed) and ProbKnot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and ProbKnot).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and ProbKnot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and ProbKnot).

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Performance of RNASampler(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(seed)

Total Base Pair Counts
Total TP 56
Total TN 31764
Total FP 43
Total FP CONTRA 2
Total FP INCONS 29
Total FP COMP 12
Total FN 108
Total Scores
MCC 0.467
Average MCC ± 95% Confidence Intervals 0.423 ± 0.366
Sensitivity 0.341
Positive Predictive Value 0.644
Nr of predictions 5

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2. Individual counts for RNASampler(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1530 10 0 10 0 20
3O58_3 0.45 0.34 0.60 12 12383 12 2 6 4 23
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.60 0.38 0.94 16 3899 1 0 1 0 26
4A1C_2 0.31 0.24 0.40 8 11761 20 0 12 8 25

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Performance of ProbKnot - scored lower in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP 57
Total TN 31699
Total FP 118
Total FP CONTRA 16
Total FP INCONS 79
Total FP COMP 23
Total FN 107
Total Scores
MCC 0.358
Average MCC ± 95% Confidence Intervals 0.342 ± 0.374
Sensitivity 0.348
Positive Predictive Value 0.375
Nr of predictions 5

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3O58_3 0.31 0.34 0.29 12 12362 41 4 25 12 23
3RKF_A 0.73 0.59 0.91 20 2189 2 1 1 0 14
3SD1_A 0.55 0.48 0.65 20 3885 11 2 9 0 22
4A1C_2 0.13 0.15 0.12 5 11738 49 7 31 11 28

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.