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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAalifold(seed) - scored higher in this pairwise comparison

  4. Performance of Multilign(20) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAalifold(seed) & Multilign(20) [.zip] - may take several seconds...


Overview

Metric RNAalifold(seed) Multilign(20)
MCC 0.591 > 0.480
Average MCC ± 95% Confidence Intervals 0.573 ± 0.114 > 0.493 ± 0.234
Sensitivity 0.381 < 0.402
Positive Predictive Value 0.923 > 0.580
Total TP 72 < 76
Total TN 24802 > 24749
Total FP 9 < 60
Total FP CONTRA 2 < 7
Total FP INCONS 4 < 48
Total FP COMP 3 < 5
Total FN 117 > 113
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAalifold(seed) and Multilign(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAalifold(seed) and Multilign(20)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAalifold(seed) and Multilign(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAalifold(seed) and Multilign(20)).

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Performance of RNAalifold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP 72
Total TN 24802
Total FP 9
Total FP CONTRA 2
Total FP INCONS 4
Total FP COMP 3
Total FN 117
Total Scores
MCC 0.591
Average MCC ± 95% Confidence Intervals 0.573 ± 0.114
Sensitivity 0.381
Positive Predictive Value 0.923
Nr of predictions 6

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.63 0.47 0.84 16 2192 3 1 2 0 18
3SD1_A 0.58 0.40 0.85 17 3896 3 1 2 0 25
4A1C_2 0.39 0.15 1.00 5 11776 2 0 0 2 28
4AOB_A 0.72 0.52 1.00 22 4349 1 0 0 1 20
4ENB_A 0.56 0.32 1.00 6 1269 0 0 0 0 13
4ENC_A 0.56 0.32 1.00 6 1320 0 0 0 0 13

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Performance of Multilign(20) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 76
Total TN 24749
Total FP 60
Total FP CONTRA 7
Total FP INCONS 48
Total FP COMP 5
Total FN 113
Total Scores
MCC 0.480
Average MCC ± 95% Confidence Intervals 0.493 ± 0.234
Sensitivity 0.402
Positive Predictive Value 0.580
Nr of predictions 6

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
3RKF_A 0.77 0.62 0.95 21 2189 1 0 1 0 13
3SD1_A 0.57 0.48 0.69 20 3887 9 1 8 0 22
4A1C_2 0.15 0.15 0.15 5 11747 33 3 26 4 28
4AOB_A 0.49 0.38 0.64 16 4346 10 1 8 1 26
4ENB_A 0.34 0.26 0.45 5 1264 6 1 5 0 14
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.