CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of RNAfold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for RNAfold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric RNAfold Multilign(seed)
MCC 0.621 > 0.538
Average MCC ± 95% Confidence Intervals 0.629 ± 0.172 > 0.478 ± 0.538
Sensitivity 0.507 > 0.420
Positive Predictive Value 0.769 > 0.699
Total TP 70 > 58
Total TN 11947 < 11955
Total FP 22 < 26
Total FP CONTRA 3 > 2
Total FP INCONS 18 < 23
Total FP COMP 1 = 1
Total FN 68 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of RNAfold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNAfold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for RNAfold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNAfold and Multilign(seed)).

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Performance of RNAfold - scored higher in this pairwise comparison

1. Total counts & total scores for RNAfold

Total Base Pair Counts
Total TP 70
Total TN 11947
Total FP 22
Total FP CONTRA 3
Total FP INCONS 18
Total FP COMP 1
Total FN 68
Total Scores
MCC 0.621
Average MCC ± 95% Confidence Intervals 0.629 ± 0.172
Sensitivity 0.507
Positive Predictive Value 0.769
Nr of predictions 4

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2. Individual counts for RNAfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.61 0.55 0.69 11 1524 5 0 5 0 9
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.