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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Sfold - scored higher in this pairwise comparison

  4. Performance of Multilign(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Sfold & Multilign(seed) [.zip] - may take several seconds...


Overview

Metric Sfold Multilign(seed)
MCC 0.600 > 0.538
Average MCC ± 95% Confidence Intervals 0.589 ± 0.229 > 0.478 ± 0.538
Sensitivity 0.471 > 0.420
Positive Predictive Value 0.774 > 0.699
Total TP 65 > 58
Total TN 11954 < 11955
Total FP 20 < 26
Total FP CONTRA 3 > 2
Total FP INCONS 16 < 23
Total FP COMP 1 = 1
Total FN 73 < 80
P-value 0.0

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Performance plots


  1. Comparison of performance of Sfold and Multilign(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Sfold and Multilign(seed)).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for Sfold and Multilign(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Sfold and Multilign(seed)).

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Performance of Sfold - scored higher in this pairwise comparison

1. Total counts & total scores for Sfold

Total Base Pair Counts
Total TP 65
Total TN 11954
Total FP 20
Total FP CONTRA 3
Total FP INCONS 16
Total FP COMP 1
Total FN 73
Total Scores
MCC 0.600
Average MCC ± 95% Confidence Intervals 0.589 ± 0.229
Sensitivity 0.471
Positive Predictive Value 0.774
Nr of predictions 4

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2. Individual counts for Sfold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A 0.45 0.35 0.58 7 1528 5 0 5 0 13
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.65 0.50 0.84 21 3891 4 1 3 0 21
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25

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Performance of Multilign(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Multilign(seed)

Total Base Pair Counts
Total TP 58
Total TN 11955
Total FP 26
Total FP CONTRA 2
Total FP INCONS 23
Total FP COMP 1
Total FN 80
Total Scores
MCC 0.538
Average MCC ± 95% Confidence Intervals 0.478 ± 0.538
Sensitivity 0.420
Positive Predictive Value 0.699
Nr of predictions 4

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2. Individual counts for Multilign(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1528 12 1 11 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.55 0.45 0.68 19 3888 9 1 8 0 23
4AOB_A 0.61 0.45 0.83 19 4348 5 0 4 1 23

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.