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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(20) - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(20) & NanoFolder [.zip] - may take several seconds...


Overview

Metric TurboFold(20) NanoFolder
MCC 0.526 > 0.316
Average MCC ± 95% Confidence Intervals 0.518 ± 0.374 > 0.345 ± 0.403
Sensitivity 0.419 > 0.324
Positive Predictive Value 0.667 > 0.316
Total TP 62 > 48
Total TN 24525 > 24466
Total FP 41 < 114
Total FP CONTRA 2 < 15
Total FP INCONS 29 < 89
Total FP COMP 10 = 10
Total FN 86 < 100
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(20) and NanoFolder).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(20) and NanoFolder).

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Performance of TurboFold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(20)

Total Base Pair Counts
Total TP 62
Total TN 24525
Total FP 41
Total FP CONTRA 2
Total FP INCONS 29
Total FP COMP 10
Total FN 86
Total Scores
MCC 0.526
Average MCC ± 95% Confidence Intervals 0.518 ± 0.374
Sensitivity 0.419
Positive Predictive Value 0.667
Nr of predictions 4

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2. Individual counts for TurboFold(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4A1C_2 0.18 0.15 0.21 5 11757 28 0 19 9 28
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 48
Total TN 24466
Total FP 114
Total FP CONTRA 15
Total FP INCONS 89
Total FP COMP 10
Total FN 100
Total Scores
MCC 0.316
Average MCC ± 95% Confidence Intervals 0.345 ± 0.403
Sensitivity 0.324
Positive Predictive Value 0.316
Nr of predictions 4

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
4A1C_3 0.48 0.46 0.51 25 7091 24 2 22 0 29
4A1C_2 0.00 0.00 0.00 0 11728 61 12 41 8 33
4AOB_A 0.33 0.29 0.39 12 4340 20 1 18 1 30
4ENC_A 0.57 0.58 0.58 11 1307 9 0 8 1 8

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.