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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of TurboFold(seed) - scored higher in this pairwise comparison

  4. Performance of UNAFold - scored lower in this pairwise comparison

  5. Compile and download dataset for TurboFold(seed) & UNAFold [.zip] - may take several seconds...


Overview

Metric TurboFold(seed) UNAFold
MCC 0.517 > 0.498
Average MCC ± 95% Confidence Intervals 0.510 ± 0.236 > 0.469 ± 0.240
Sensitivity 0.422 < 0.426
Positive Predictive Value 0.642 > 0.589
Total TP 111 < 112
Total TN 33387 > 33370
Total FP 72 < 90
Total FP CONTRA 8 < 13
Total FP INCONS 54 < 65
Total FP COMP 10 < 12
Total FN 152 > 151
P-value 0.0

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Performance plots


  1. Comparison of performance of TurboFold(seed) and UNAFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for TurboFold(seed) and UNAFold).

  2. Comparison of average Matthews Correlation Coefficients (MCCs) for TurboFold(seed) and UNAFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for TurboFold(seed) and UNAFold).

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Performance of TurboFold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for TurboFold(seed)

Total Base Pair Counts
Total TP 111
Total TN 33387
Total FP 72
Total FP CONTRA 8
Total FP INCONS 54
Total FP COMP 10
Total FN 152
Total Scores
MCC 0.517
Average MCC ± 95% Confidence Intervals 0.510 ± 0.236
Sensitivity 0.422
Positive Predictive Value 0.642
Nr of predictions 8

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2. Individual counts for TurboFold(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.59 0.48 0.74 20 3889 7 1 6 0 22
4A1C_2 0.15 0.15 0.15 5 11748 37 3 25 9 28
4A1C_3 0.69 0.57 0.84 31 7103 6 0 6 0 23
4AOB_A 0.56 0.40 0.77 17 4349 6 1 4 1 25
4ENB_A 0.69 0.47 1.00 9 1266 0 0 0 0 10
4ENC_A 0.65 0.47 0.90 9 1316 1 1 0 0 10

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Performance of UNAFold - scored lower in this pairwise comparison

1. Total counts & total scores for UNAFold

Total Base Pair Counts
Total TP 112
Total TN 33370
Total FP 90
Total FP CONTRA 13
Total FP INCONS 65
Total FP COMP 12
Total FN 151
Total Scores
MCC 0.498
Average MCC ± 95% Confidence Intervals 0.469 ± 0.240
Sensitivity 0.426
Positive Predictive Value 0.589
Nr of predictions 8

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2. Individual counts for UNAFold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
2LC8_A -0.01 0.00 0.00 0 1525 15 2 13 0 20
3RKF_A 0.76 0.59 1.00 20 2191 0 0 0 0 14
3SD1_A 0.64 0.52 0.79 22 3888 6 1 5 0 20
4A1C_2 0.14 0.15 0.14 5 11745 42 5 26 11 28
4A1C_3 0.70 0.59 0.82 32 7101 7 1 6 0 22
4AOB_A 0.50 0.40 0.63 17 4344 11 2 8 1 25
4ENB_A 0.70 0.58 0.85 11 1262 2 1 1 0 8
4ENC_A 0.32 0.26 0.42 5 1314 7 1 6 0 14

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.