CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of CMfinder(seed) - scored higher in this pairwise comparison

  4. Performance of Mastr(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for CMfinder(seed) & Mastr(seed) [.zip] - may take several seconds...


Overview

Metric CMfinder(seed) Mastr(seed)
MCC 0.486 > 0.312
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044 > 0.298 ± 0.062
Sensitivity 0.312 > 0.118
Positive Predictive Value 0.757 < 0.828
Total TP 1905 > 717
Total TN 2881233 < 2882884
Total FP 688 > 221
Total FP CONTRA 40 > 17
Total FP INCONS 572 > 132
Total FP COMP 76 > 72
Total FN 4192 < 5380
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of CMfinder(seed) and Mastr(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CMfinder(seed) and Mastr(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CMfinder(seed) and Mastr(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for CMfinder(seed) and Mastr(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CMfinder(seed) and Mastr(seed)).

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Performance of CMfinder(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 1905
Total TN 2881233
Total FP 688
Total FP CONTRA 40
Total FP INCONS 572
Total FP COMP 76
Total FN 4192
Total Scores
MCC 0.486
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044
Sensitivity 0.312
Positive Predictive Value 0.757
Nr of predictions 129

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.37 0.14 1.00 16 103724 0 0 0 0 99
CRW_00016 0.36 0.14 0.89 17 77402 2 0 2 0 103
CRW_00610 0.49 0.31 0.78 25 36283 7 1 6 0 56
CRW_00613 0.54 0.33 0.87 26 34950 4 0 4 0 52
CRW_00614 0.46 0.25 0.88 14 121755 9 0 2 7 43
CRW_00618 0.36 0.13 1.00 8 56272 0 0 0 0 53
CRW_00633 0.32 0.12 0.81 13 63530 3 1 2 0 93
CRW_00634 0.40 0.17 0.94 16 64603 1 0 1 0 78
CRW_00670 0.32 0.18 0.55 22 70085 18 0 18 0 98
CRW_00671 0.20 0.09 0.41 11 62808 16 0 16 0 106
CRW_00672 0.38 0.15 0.94 17 72372 1 0 1 0 94
CRW_00674 0.40 0.17 0.95 21 83414 1 0 1 0 103
CRW_00676 0.12 0.04 0.33 5 93513 10 1 9 0 110
CRW_00692 0.41 0.17 1.00 15 68620 0 0 0 0 75
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_00810 0.76 0.59 1.00 10 1071 0 0 0 0 7
PDB_00827 0.25 0.10 0.62 8 27015 5 0 5 0 73
PDB_01050 0.68 0.46 1.00 6 624 1 0 0 1 7
PDB_01051 0.83 0.69 1.00 9 894 4 0 0 4 4
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00603 0.70 0.60 0.81 21 13504 7 0 5 2 14
RFA_00604 0.63 0.51 0.78 18 13507 8 0 5 3 17
RFA_00605 0.14 0.06 0.33 2 15219 5 0 4 1 33
RFA_00606 0.34 0.21 0.57 8 21307 8 2 4 2 31
RFA_00607 0.08 0.06 0.13 2 17750 15 3 11 1 34
RFA_00609 0.32 0.22 0.47 8 17938 12 2 7 3 29
RFA_00610 0.39 0.30 0.52 11 17184 13 2 8 3 26
RFA_00611 0.65 0.51 0.82 18 13019 5 0 4 1 17
RFA_00613 0.70 0.57 0.87 20 12857 4 0 3 1 15
RFA_00615 0.57 0.49 0.68 17 13341 10 0 8 2 18
RFA_00620 0.00 0.00 0.00 0 21939 6 0 6 0 39
RFA_00626 0.44 0.32 0.60 28 56569 22 2 17 3 59
RFA_00627 0.53 0.39 0.72 34 56906 15 3 10 2 53
RFA_00628 0.58 0.43 0.77 37 57243 14 3 8 3 49
RFA_00630 0.45 0.32 0.64 28 56909 17 3 13 1 59
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00639 0.00 0.00 0.00 0 54575 44 6 34 4 87
RFA_00642 0.44 0.28 0.71 5 2919 2 0 2 0 13
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.00 0.00 0.00 0 2693 8 0 8 0 18
RFA_00645 0.29 0.17 0.50 3 2409 3 0 3 0 15
RFA_00649 0.35 0.22 0.57 4 2138 3 0 3 0 14
RFA_00651 0.35 0.22 0.57 4 2073 3 0 3 0 14
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.38 0.22 0.67 4 2409 2 0 2 0 14
RFA_00658 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00659 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00664 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00667 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00668 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00672 0.41 0.31 0.57 4 896 3 0 3 0 9
RFA_00673 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00674 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00675 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00677 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00704 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00705 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00710 0.32 0.21 0.50 3 984 3 0 3 0 11
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.30 0.14 0.67 2 943 2 0 1 1 12
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.30 0.21 0.43 3 896 4 0 4 0 11
RFA_00730 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00731 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00733 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00734 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00736 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00737 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00745 0.91 0.83 1.00 10 936 0 0 0 0 2
RFA_00749 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00758 0.86 0.75 1.00 9 894 0 0 0 0 3
RFA_00762 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00763 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00764 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00765 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00791 0.92 0.88 0.97 28 5122 1 0 1 0 4
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10
RFA_00814 0.68 0.51 0.91 21 25177 2 0 2 0 20
RFA_00815 0.68 0.51 0.91 21 24508 2 0 2 0 20
RFA_00816 0.68 0.51 0.91 21 23197 2 0 2 0 20
RFA_00817 0.68 0.56 0.82 23 21917 5 0 5 0 18
RFA_00818 0.60 0.49 0.74 20 20274 8 1 6 1 21
RFA_00819 0.62 0.51 0.75 21 27938 7 0 7 0 20
SRP_00016 0.54 0.35 0.83 38 47849 8 0 8 0 71
SRP_00130 0.50 0.32 0.78 31 49730 10 1 8 1 66
SRP_00142 0.46 0.37 0.58 34 45997 26 1 24 1 59
SRP_00143 0.50 0.30 0.86 30 49735 5 0 5 0 71
SRP_00144 0.54 0.37 0.80 35 46621 11 0 9 2 59
SRP_00197 0.46 0.26 0.84 26 49424 5 0 5 0 75
SRP_00198 0.56 0.37 0.84 38 50995 7 0 7 0 65
SRP_00199 0.54 0.35 0.82 37 50995 8 0 8 0 68
SRP_00201 0.54 0.35 0.83 39 47848 8 0 8 0 72
SRP_00202 0.43 0.21 0.86 25 54256 4 0 4 0 92
SRP_00203 0.51 0.34 0.77 36 48781 12 0 11 1 69
SRP_00204 0.52 0.34 0.80 35 49097 9 1 8 0 67
SRP_00206 0.55 0.36 0.83 39 47848 8 0 8 0 69
SRP_00208 0.52 0.33 0.83 33 46625 7 1 6 0 68
SRP_00255 0.49 0.27 0.89 25 47558 3 0 3 0 69
SRP_00276 0.51 0.33 0.80 36 50676 9 0 9 0 74
SRP_00278 0.52 0.33 0.81 35 46013 8 0 8 0 70
SRP_00321 0.42 0.21 0.82 23 47558 5 1 4 0 85
SRP_00322 0.52 0.33 0.82 36 48472 8 0 8 0 73
SRP_00323 0.54 0.34 0.88 36 47237 5 0 5 0 71
SRP_00330 0.44 0.23 0.85 22 50060 5 0 4 1 73
SRP_00332 0.44 0.25 0.75 27 50367 9 0 9 0 79
SRP_00339 0.56 0.39 0.79 37 44504 10 2 8 0 57

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Performance of Mastr(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Mastr(seed)

Total Base Pair Counts
Total TP 717
Total TN 2882884
Total FP 221
Total FP CONTRA 17
Total FP INCONS 132
Total FP COMP 72
Total FN 5380
Total Scores
MCC 0.312
Average MCC ± 95% Confidence Intervals 0.298 ± 0.062
Sensitivity 0.118
Positive Predictive Value 0.828
Nr of predictions 129

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2. Individual counts for Mastr(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.00 0.00 0.00 0 103740 0 0 0 0 115
CRW_00016 0.00 0.00 0.00 0 77421 0 0 0 0 120
CRW_00610 0.00 0.00 0.00 0 36315 0 0 0 0 81
CRW_00613 0.00 0.00 0.00 0 34980 0 0 0 0 78
CRW_00614 0.00 0.00 0.00 0 121771 0 0 0 0 57
CRW_00618 0.00 0.00 0.00 0 56280 0 0 0 0 61
CRW_00633 0.00 0.00 0.00 0 63546 0 0 0 0 106
CRW_00634 0.00 0.00 0.00 0 64620 0 0 0 0 94
CRW_00670 0.00 0.00 0.00 0 70125 0 0 0 0 120
CRW_00671 0.00 0.00 0.00 0 62835 0 0 0 0 117
CRW_00672 0.00 0.00 0.00 0 72390 0 0 0 0 111
CRW_00674 0.00 0.00 0.00 0 83436 0 0 0 0 124
CRW_00676 0.00 0.00 0.00 0 93528 0 0 0 0 115
CRW_00692 0.00 0.00 0.00 0 68635 0 0 0 0 90
PDB_00005 0.60 0.43 0.86 6 939 2 0 1 1 8
PDB_00012 0.00 0.00 0.00 0 406 0 0 0 0 7
PDB_00213 0.81 0.73 0.91 30 5017 3 0 3 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 0.00 0.00 0.00 0 2701 0 0 0 0 23
PDB_00810 0.43 0.35 0.55 6 1070 6 0 5 1 11
PDB_00827 0.00 0.00 0.00 0 27028 0 0 0 0 81
PDB_01050 0.78 0.62 1.00 8 622 2 0 0 2 5
PDB_01051 0.00 0.00 0.00 0 903 0 0 0 0 13
PDB_01092 0.00 0.00 0.00 0 10153 0 0 0 0 52
PDB_01152 0.81 0.79 0.85 11 548 2 0 2 0 3
RFA_00603 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00604 0.00 0.00 0.00 0 13530 0 0 0 0 35
RFA_00605 0.00 0.00 0.00 0 15225 0 0 0 0 35
RFA_00606 0.00 0.00 0.00 0 21321 0 0 0 0 39
RFA_00607 0.00 0.00 0.00 0 17766 0 0 0 0 36
RFA_00609 0.00 0.00 0.00 0 17955 0 0 0 0 37
RFA_00610 0.00 0.00 0.00 0 17205 0 0 0 0 37
RFA_00611 0.00 0.00 0.00 0 13041 0 0 0 0 35
RFA_00613 0.00 0.00 0.00 0 12880 0 0 0 0 35
RFA_00615 0.00 0.00 0.00 0 13366 0 0 0 0 35
RFA_00620 0.00 0.00 0.00 0 21945 0 0 0 0 39
RFA_00626 0.61 0.51 0.75 44 56557 22 2 13 7 43
RFA_00627 0.84 0.75 0.94 65 56884 16 0 4 12 22
RFA_00628 0.88 0.80 0.96 69 57219 11 0 3 8 17
RFA_00630 0.80 0.70 0.91 61 56886 14 0 6 8 26
RFA_00632 0.00 0.00 0.00 0 4095 0 0 0 0 28
RFA_00636 0.00 0.00 0.00 0 4005 0 0 0 0 28
RFA_00639 0.00 0.00 0.00 0 54615 0 0 0 0 87
RFA_00642 0.58 0.33 1.00 6 2920 0 0 0 0 12
RFA_00643 0.29 0.17 0.50 3 2205 3 0 3 0 15
RFA_00644 0.62 0.39 1.00 7 2694 0 0 0 0 11
RFA_00645 0.58 0.33 1.00 6 2409 0 0 0 0 12
RFA_00649 0.67 0.44 1.00 8 2137 0 0 0 0 10
RFA_00651 0.67 0.44 1.00 8 2072 0 0 0 0 10
RFA_00653 0.00 0.00 0.00 0 2143 2 0 2 0 18
RFA_00654 0.62 0.39 1.00 7 2408 0 0 0 0 11
RFA_00658 0.56 0.43 0.75 6 1120 3 0 2 1 8
RFA_00659 0.50 0.36 0.71 5 1121 3 0 2 1 9
RFA_00664 0.27 0.07 1.00 1 989 0 0 0 0 13
RFA_00667 -0.01 0.00 0.00 0 988 2 0 2 0 14
RFA_00668 0.50 0.36 0.71 5 983 3 0 2 1 9
RFA_00672 0.28 0.08 1.00 1 902 0 0 0 0 12
RFA_00673 0.46 0.21 1.00 3 1125 0 0 0 0 11
RFA_00674 0.53 0.29 1.00 4 1124 0 0 0 0 10
RFA_00675 0.00 0.00 0.00 0 989 1 0 1 0 14
RFA_00677 0.46 0.21 1.00 3 987 0 0 0 0 11
RFA_00678 0.43 0.29 0.67 4 940 2 0 2 0 10
RFA_00680 0.65 0.43 1.00 6 1122 0 0 0 0 8
RFA_00684 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00685 0.56 0.43 0.75 6 982 3 0 2 1 8
RFA_00704 -0.01 0.00 0.00 0 988 2 0 2 0 14
RFA_00705 0.27 0.07 1.00 1 1034 0 0 0 0 13
RFA_00706 0.30 0.14 0.67 2 1032 1 0 1 0 12
RFA_00707 0.50 0.36 0.71 5 1028 3 0 2 1 9
RFA_00708 0.40 0.21 0.75 3 1031 1 0 1 0 11
RFA_00709 0.65 0.43 1.00 6 984 0 0 0 0 8
RFA_00710 0.65 0.43 1.00 6 984 0 0 0 0 8
RFA_00711 0.27 0.07 1.00 1 1034 0 0 0 0 13
RFA_00715 0.35 0.21 0.60 3 941 2 0 2 0 11
RFA_00716 0.26 0.14 0.50 2 942 2 0 2 0 12
RFA_00717 0.62 0.50 0.78 7 894 2 0 2 0 7
RFA_00730 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00731 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00733 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00734 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00736 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00737 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00745 0.91 0.83 1.00 10 936 2 0 0 2 2
RFA_00749 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00758 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00762 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00763 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00764 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00765 0.91 0.83 1.00 10 893 2 0 0 2 2
RFA_00769 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00770 0.68 0.56 0.83 10 2004 2 0 2 0 8
RFA_00773 0.64 0.50 0.82 9 1942 2 1 1 0 9
RFA_00779 0.65 0.56 0.77 10 1940 3 0 3 0 8
RFA_00781 0.92 0.94 0.91 30 5017 3 2 1 0 2
RFA_00786 0.73 0.75 0.71 24 5016 10 2 8 0 8
RFA_00791 0.64 0.66 0.64 21 5118 12 2 10 0 11
RFA_00792 0.92 0.94 0.91 30 5017 3 2 1 0 2
RFA_00801 0.40 0.41 0.39 13 5017 20 2 18 0 19
RFA_00808 -0.01 0.00 0.00 0 2001 17 2 13 2 16
RFA_00809 0.40 0.38 0.43 6 2131 8 1 7 0 10
RFA_00814 0.00 0.00 0.00 0 25200 0 0 0 0 41
RFA_00815 0.00 0.00 0.00 0 24531 0 0 0 0 41
RFA_00816 0.00 0.00 0.00 0 23220 0 0 0 0 41
RFA_00817 0.00 0.00 0.00 0 21945 0 0 0 0 41
RFA_00818 0.00 0.00 0.00 0 20301 0 0 0 0 41
RFA_00819 0.00 0.00 0.00 0 27966 0 0 0 0 41
SRP_00016 0.00 0.00 0.00 0 47895 0 0 0 0 109
SRP_00130 0.00 0.00 0.00 0 49770 0 0 0 0 97
SRP_00142 0.00 0.00 0.00 0 46056 0 0 0 0 93
SRP_00143 0.00 0.00 0.00 0 49770 0 0 0 0 101
SRP_00144 0.00 0.00 0.00 0 46665 0 0 0 0 94
SRP_00197 0.00 0.00 0.00 0 49455 0 0 0 0 101
SRP_00198 0.00 0.00 0.00 0 51040 0 0 0 0 103
SRP_00199 0.00 0.00 0.00 0 51040 0 0 0 0 105
SRP_00201 0.00 0.00 0.00 0 47895 0 0 0 0 111
SRP_00202 0.00 0.00 0.00 0 54285 0 0 0 0 117
SRP_00203 0.00 0.00 0.00 0 48828 0 0 0 0 105
SRP_00204 0.00 0.00 0.00 0 49141 0 0 0 0 102
SRP_00206 0.00 0.00 0.00 0 47895 0 0 0 0 108
SRP_00208 0.00 0.00 0.00 0 46665 0 0 0 0 101
SRP_00255 0.00 0.00 0.00 0 47586 0 0 0 0 94
SRP_00276 0.00 0.00 0.00 0 50721 0 0 0 0 110
SRP_00278 0.00 0.00 0.00 0 46056 0 0 0 0 105
SRP_00321 0.00 0.00 0.00 0 47586 0 0 0 0 108
SRP_00322 0.00 0.00 0.00 0 48516 0 0 0 0 109
SRP_00323 0.00 0.00 0.00 0 47278 0 0 0 0 107
SRP_00330 0.00 0.00 0.00 0 50086 0 0 0 0 95
SRP_00332 0.00 0.00 0.00 0 50403 0 0 0 0 106
SRP_00339 0.00 0.00 0.00 0 44551 0 0 0 0 94

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.