CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	CentroidAlifold(20)		Carnac(seed)
MCC	0.819	>	0.398
Average MCC ± 95% Confidence Intervals	0.779 ± 0.049	>	0.318 ± 0.085
Sensitivity	0.720	>	0.173
Positive Predictive Value	0.932	>	0.918
Total TP	2299	>	552
Total TN	2007458	<	2009323
Total FP	399	>	105
Total FP CONTRA	10	=	10
Total FP INCONS	157	>	39
Total FP COMP	232	>	56
Total FN	894	<	2641
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of CentroidAlifold(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for CentroidAlifold(20) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for CentroidAlifold(20) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for CentroidAlifold(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for CentroidAlifold(20) and Carnac(seed)).

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Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

Total Base Pair Counts
Total TP	2299
Total TN	2007458
Total FP	399
Total FP CONTRA	10
Total FP INCONS	157
Total FP COMP	232
Total FN	894

Total Scores
MCC	0.819
Average MCC ± 95% Confidence Intervals	0.779 ± 0.049
Sensitivity	0.720
Positive Predictive Value	0.932
Nr of predictions	82

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2. Individual counts for CentroidAlifold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.91	0.86	0.95	394	1085188	51	6	13	32	64
CRW_01484	5S_rRNA links to Rfam database...	0.93	0.87	1.00	34	7469	2	0	0	2	5
CRW_01499	5S_rRNA links to Rfam database...	0.69	0.61	0.78	25	7969	7	0	7	0	16
CRW_01603	5S_rRNA links to Rfam database...	0.86	0.78	0.94	29	7109	3	0	2	1	8
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	2	0	0	2	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.85	0.73	1.00	30	5020	0	0	0	0	11
PDB_00553	mir-TAR links to Rfam database...	1.00	1.00	1.00	11	454	0	0	0	0	0
PDB_00810	s2m links to Rfam database...	0.87	0.76	1.00	13	1068	1	0	0	1	4
PDB_01050	UnaL2 links to Rfam database...	0.68	0.46	1.00	6	624	2	0	0	2	7
PDB_01152	HIV_FS2 links to Rfam database...	0.80	0.64	1.00	9	552	0	0	0	0	5
RFA_00389	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00390	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00391	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00409	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00416	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	2	0	0	2	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00434	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00436	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00440	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1471	2	0	0	2	1
RFA_00442	Hammerhead_3 links to Rfam database...	0.97	0.93	1.00	14	1417	2	0	0	2	1
RFA_00587	Y_RNA links to Rfam database...	0.97	0.93	1.00	14	4837	3	0	0	3	1
RFA_00599	Telomerase-vert links to Rfam database...	0.89	0.83	0.96	92	101379	9	1	3	5	19
RFA_00601	Telomerase-vert links to Rfam database...	0.90	0.86	0.93	98	99130	13	1	6	6	16
RFA_00602	Telomerase-vert links to Rfam database...	0.87	0.84	0.91	97	101368	18	1	9	8	19
RFA_00658	Hammerhead_1 links to Rfam database...	0.53	0.43	0.67	6	1119	4	0	3	1	8
RFA_00664	Hammerhead_1 links to Rfam database...	0.50	0.36	0.71	5	983	2	0	2	0	9
RFA_00667	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	982	3	0	3	0	9
RFA_00668	Hammerhead_1 links to Rfam database...	0.35	0.29	0.44	4	981	5	0	5	0	10
RFA_00672	Hammerhead_1 links to Rfam database...	0.29	0.23	0.38	3	895	5	0	5	0	10
RFA_00673	Hammerhead_1 links to Rfam database...	0.53	0.43	0.67	6	1119	4	0	3	1	8
RFA_00674	Hammerhead_1 links to Rfam database...	0.56	0.43	0.75	6	1120	3	0	2	1	8
RFA_00675	Hammerhead_1 links to Rfam database...	0.35	0.29	0.44	4	981	5	0	5	0	10
RFA_00677	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	982	3	0	3	0	9
RFA_00678	Hammerhead_1 links to Rfam database...	0.56	0.43	0.75	6	938	3	0	2	1	8
RFA_00680	Hammerhead_1 links to Rfam database...	0.53	0.43	0.67	6	1119	4	0	3	1	8
RFA_00704	Hammerhead_1 links to Rfam database...	0.50	0.36	0.71	5	983	3	0	2	1	9
RFA_00707	Hammerhead_1 links to Rfam database...	0.50	0.36	0.71	5	1028	3	0	2	1	9
RFA_00715	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	938	3	0	3	0	9
RFA_00717	Hammerhead_1 links to Rfam database...	0.54	0.36	0.83	5	897	1	0	1	0	9
RFA_00730	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00731	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00733	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00734	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00736	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00737	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00745	s2m links to Rfam database...	1.00	1.00	1.00	12	934	2	0	0	2	0
RFA_00749	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00758	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00762	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00763	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00764	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00765	s2m links to Rfam database...	1.00	1.00	1.00	12	891	2	0	0	2	0
RFA_00786	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00791	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5121	0	0	0	0	2
RFA_00792	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
RFA_00801	Gammaretro_CES links to Rfam database...	0.97	0.94	1.00	30	5020	0	0	0	0	2
SPR_00273	tRNA links to Rfam database...	0.95	0.95	0.95	20	2829	1	0	1	0	1
SPR_00721	tRNA links to Rfam database...	1.00	1.00	1.00	21	2905	0	0	0	0	0
SRP_00011	Plant_SRP links to Rfam database...	0.82	0.76	0.89	79	46271	16	0	10	6	25
SRP_00015	Plant_SRP links to Rfam database...	0.86	0.82	0.90	81	46270	20	0	9	11	18
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.72	0.55	0.95	18	5546	5	0	1	4	15
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.66	0.47	0.94	16	5761	5	0	1	4	18
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.59	0.35	1.00	12	5448	4	0	0	4	22
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.45	0.21	1.00	7	5558	4	0	0	4	27
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.69	0.69	0.69	20	5966	17	0	9	8	9
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.38	0.15	1.00	6	6322	5	0	0	5	35
SRP_00152	Plant_SRP links to Rfam database...	0.83	0.76	0.91	78	45667	13	0	8	5	25
SRP_00178	Plant_SRP links to Rfam database...	0.78	0.62	0.98	63	45689	5	0	1	4	39
SRP_00179	Plant_SRP links to Rfam database...	0.89	0.79	1.00	83	45973	8	0	0	8	22
SRP_00181	Plant_SRP links to Rfam database...	0.82	0.77	0.88	79	45966	17	0	11	6	23
SRP_00182	Plant_SRP links to Rfam database...	0.91	0.87	0.95	88	45963	10	0	5	5	13
SRP_00184	Plant_SRP links to Rfam database...	0.87	0.83	0.91	83	45965	15	0	8	7	17
SRP_00188	Plant_SRP links to Rfam database...	0.86	0.78	0.95	62	31060	5	0	3	2	17
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.41	0.17	1.00	6	6897	1	0	0	1	30
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.66	0.44	1.00	15	5445	4	0	0	4	19
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.79	0.70	0.90	28	6755	7	1	2	4	12
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.63	0.39	1.00	15	6888	4	0	0	4	23
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.64	0.45	0.91	40	36271	9	0	4	5	48
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.44	0.19	1.00	7	5453	4	0	0	4	29
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.47	0.23	1.00	7	4746	4	0	0	4	24
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.44	0.19	1.00	7	5349	4	0	0	4	29
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.41	0.17	1.00	6	6780	4	0	0	4	29

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	552
Total TN	2009323
Total FP	105
Total FP CONTRA	10
Total FP INCONS	39
Total FP COMP	56
Total FN	2641

Total Scores
MCC	0.398
Average MCC ± 95% Confidence Intervals	0.318 ± 0.085
Sensitivity	0.173
Positive Predictive Value	0.918
Nr of predictions	82

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00024	SSU_rRNA_archaea links to Rfam database...	0.73	0.57	0.93	261	1085321	35	6	13	16	197
CRW_01484	5S_rRNA links to Rfam database...	0.00	0.00	0.00	0	7503	0	0	0	0	39
CRW_01499	5S_rRNA links to Rfam database...	0.00	0.00	0.00	0	8001	0	0	0	0	41
CRW_01603	5S_rRNA links to Rfam database...	0.00	0.00	0.00	0	7140	0	0	0	0	37
PDB_00012	mir-TAR links to Rfam database...	1.00	1.00	1.00	7	399	3	0	0	3	0
PDB_00213	Gammaretro_CES links to Rfam database...	0.58	0.34	1.00	14	5036	0	0	0	0	27
PDB_00553	mir-TAR links to Rfam database...	0.79	0.64	1.00	7	458	0	0	0	0	4
PDB_00810	s2m links to Rfam database...	0.64	0.41	1.00	7	1074	0	0	0	0	10
PDB_01050	UnaL2 links to Rfam database...	0.62	0.38	1.00	5	625	1	0	0	1	8
PDB_01152	HIV_FS2 links to Rfam database...	0.88	0.79	1.00	11	550	0	0	0	0	3
RFA_00389	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00391	Hammerhead_3 links to Rfam database...	0.93	0.87	1.00	13	1418	2	0	0	2	2
RFA_00409	Hammerhead_3 links to Rfam database...	0.77	0.60	1.00	9	1422	1	0	0	1	6
RFA_00416	Hammerhead_3 links to Rfam database...	0.93	0.93	0.93	14	1470	4	0	1	3	1
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00434	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00436	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00440	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	2	0	0	2	0
RFA_00442	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00587	Y_RNA links to Rfam database...	0.00	0.00	0.00	0	4851	0	0	0	0	15
RFA_00599	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	111
RFA_00601	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	99235	0	0	0	0	114
RFA_00602	Telomerase-vert links to Rfam database...	0.00	0.00	0.00	0	101475	0	0	0	0	116
RFA_00658	Hammerhead_1 links to Rfam database...	0.40	0.29	0.57	4	1121	5	0	3	2	10
RFA_00664	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00667	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	985	5	1	4	0	14
RFA_00668	Hammerhead_1 links to Rfam database...	0.50	0.43	0.60	6	980	4	0	4	0	8
RFA_00672	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	903	0	0	0	0	13
RFA_00673	Hammerhead_1 links to Rfam database...	0.47	0.36	0.63	5	1120	4	0	3	1	9
RFA_00674	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	1128	0	0	0	0	14
RFA_00675	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00677	Hammerhead_1 links to Rfam database...	0.53	0.43	0.67	6	981	4	0	3	1	8
RFA_00678	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	946	0	0	0	0	14
RFA_00680	Hammerhead_1 links to Rfam database...	0.84	0.71	1.00	10	1118	2	0	0	2	4
RFA_00704	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	990	0	0	0	0	14
RFA_00707	Hammerhead_1 links to Rfam database...	0.53	0.29	1.00	4	1031	0	0	0	0	10
RFA_00715	Hammerhead_1 links to Rfam database...	-0.01	0.00	0.00	0	943	3	1	2	0	14
RFA_00717	Hammerhead_1 links to Rfam database...	0.00	0.00	0.00	0	903	0	0	0	0	14
RFA_00730	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00731	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00733	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00734	s2m links to Rfam database...	0.64	0.42	1.00	5	898	0	0	0	0	7
RFA_00736	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00737	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00745	s2m links to Rfam database...	0.64	0.42	1.00	5	941	1	0	0	1	7
RFA_00749	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00758	s2m links to Rfam database...	0.00	0.00	0.00	0	903	0	0	0	0	12
RFA_00762	s2m links to Rfam database...	0.64	0.42	1.00	5	898	0	0	0	0	7
RFA_00763	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00764	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00765	s2m links to Rfam database...	0.64	0.42	1.00	5	898	1	0	0	1	7
RFA_00786	Gammaretro_CES links to Rfam database...	0.25	0.13	0.50	4	5042	4	1	3	0	28
RFA_00791	Gammaretro_CES links to Rfam database...	0.00	0.00	0.00	0	5151	0	0	0	0	32
RFA_00792	Gammaretro_CES links to Rfam database...	0.00	0.00	0.00	0	5046	4	1	3	0	32
RFA_00801	Gammaretro_CES links to Rfam database...	0.00	0.00	0.00	0	5050	0	0	0	0	32
SPR_00273	tRNA links to Rfam database...	0.00	0.00	0.00	0	2850	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SRP_00011	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46360	0	0	0	0	104
SRP_00015	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46360	0	0	0	0	99
SRP_00020	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	33
SRP_00058	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5778	0	0	0	0	34
SRP_00084	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00152	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45753	0	0	0	0	103
SRP_00178	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45753	0	0	0	0	102
SRP_00179	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	105
SRP_00181	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	102
SRP_00182	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	101
SRP_00184	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	100
SRP_00188	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	31125	0	0	0	0	79
SRP_00200	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	36
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36315	0	0	0	0	88
SRP_00338	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	36
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36
SRP_00367	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of CentroidAlifold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for CentroidAlifold(20)

2. Individual counts for CentroidAlifold(20) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]