CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of HotKnots - scored higher in this pairwise comparison

  4. Performance of NanoFolder - scored lower in this pairwise comparison

  5. Compile and download dataset for HotKnots & NanoFolder [.zip] - may take several seconds...


Overview

Metric HotKnots NanoFolder
MCC 0.656 > 0.339
Average MCC ± 95% Confidence Intervals 0.648 ± 0.057 > 0.390 ± 0.054
Sensitivity 0.650 > 0.391
Positive Predictive Value 0.668 > 0.302
Total TP 1779 > 1070
Total TN 417943 > 417065
Total FP 1046 < 2604
Total FP CONTRA 125 < 498
Total FP INCONS 760 < 1974
Total FP COMP 161 > 132
Total FN 960 < 1669
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of HotKnots and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for HotKnots and NanoFolder).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for HotKnots and NanoFolder).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for HotKnots and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for HotKnots and NanoFolder).

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Performance of HotKnots - scored higher in this pairwise comparison

1. Total counts & total scores for HotKnots

Total Base Pair Counts
Total TP 1779
Total TN 417943
Total FP 1046
Total FP CONTRA 125
Total FP INCONS 760
Total FP COMP 161
Total FN 960
Total Scores
MCC 0.656
Average MCC ± 95% Confidence Intervals 0.648 ± 0.057
Sensitivity 0.650
Positive Predictive Value 0.668
Nr of predictions 117

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2. Individual counts for HotKnots [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01535 0.84 0.78 0.91 29 7108 8 0 3 5 8
CRW_01539 0.83 0.76 0.90 28 7109 9 0 3 6 9
CRW_01563 0.86 0.81 0.91 30 6870 4 0 3 1 7
CRW_01583 0.80 0.76 0.85 28 7107 9 0 5 4 9
CRW_01590 0.85 0.81 0.88 30 7106 7 0 4 3 7
CRW_01593 0.82 0.78 0.85 29 7106 10 0 5 5 8
CRW_01595 0.74 0.70 0.79 26 8482 12 0 7 5 11
CRW_01603 0.83 0.78 0.88 29 7107 7 0 4 3 8
CRW_01617 0.92 0.89 0.94 33 7105 6 0 2 4 4
CRW_01625 0.88 0.86 0.89 32 7104 7 0 4 3 5
PDB_00011 - 0.91 0.83 1.00 10 266 0 0 0 0 2
PDB_00017 - 0.77 0.60 1.00 9 694 0 0 0 0 6
PDB_00036 - -0.01 0.00 0.00 0 3464 24 1 21 2 27
PDB_00070 0.68 0.67 0.70 16 2827 7 1 6 0 8
PDB_00113 - 0.94 0.89 1.00 8 223 0 0 0 0 1
PDB_00119 - 0.95 0.90 1.00 9 244 0 0 0 0 1
PDB_00136 - 0.76 0.73 0.79 19 2391 5 0 5 0 7
PDB_00137 - 0.87 0.77 1.00 10 396 0 0 0 0 3
PDB_00160 - 0.94 0.89 1.00 8 268 0 0 0 0 1
PDB_00178 - 0.90 0.82 1.00 9 519 1 0 0 1 2
PDB_00221 - 0.88 0.78 1.00 7 246 0 0 0 0 2
PDB_00312 - 0.46 0.44 0.50 4 427 4 0 4 0 5
PDB_00326 - 0.60 0.54 0.68 15 3719 7 0 7 0 13
PDB_00341 - 0.20 0.19 0.25 3 691 9 0 9 0 13
PDB_00349 - 0.24 0.29 0.22 4 928 14 4 10 0 10
PDB_00417 - 0.10 0.11 0.11 6 14140 50 6 44 0 50
PDB_00430 0.72 0.72 0.72 18 3215 7 3 4 0 7
PDB_00527 - -0.02 0.00 0.00 0 294 6 1 5 0 5
PDB_00565 - 0.77 0.70 0.85 35 8087 7 0 6 1 15
PDB_00570 - 0.82 0.82 0.82 18 2256 4 2 2 0 4
PDB_00571 0.17 0.16 0.19 4 3300 17 6 11 0 21
PDB_00573 - 0.75 0.71 0.80 24 6640 10 0 6 4 10
PDB_00584 - 0.18 0.18 0.20 3 1470 12 1 11 0 14
PDB_00698 - 0.94 0.89 1.00 17 844 0 0 0 0 2
PDB_00725 - 0.93 0.87 1.00 13 582 0 0 0 0 2
PDB_00734 - 0.83 0.70 1.00 7 224 0 0 0 0 3
PDB_00823 - -0.03 0.00 0.00 0 186 4 0 4 0 9
PDB_00828 0.88 0.78 1.00 21 2464 0 0 0 0 6
PDB_00851 - 0.44 0.39 0.50 16 4721 16 0 16 0 25
PDB_00890 - 1.00 1.00 1.00 14 689 0 0 0 0 0
PDB_00923 - 1.00 1.00 1.00 6 184 0 0 0 0 0
PDB_00994 - 0.00 0.00 0.00 0 10530 55 15 40 0 42
PDB_01009 0.52 0.57 0.48 12 2460 13 5 8 0 9
PDB_01051 0.75 0.69 0.82 9 892 6 0 2 4 4
PDB_01074 - -0.01 0.00 0.00 0 2746 29 3 26 0 25
PDB_01130 - -0.01 0.00 0.00 0 1746 24 6 18 0 20
PDB_01199 - 0.18 0.17 0.22 4 2127 14 0 14 0 20
PDB_01236 0.61 0.57 0.65 31 11580 20 0 17 3 23
RFA_00416 0.93 0.93 0.93 14 1470 4 0 1 3 1
RFA_00434 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00436 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00442 1.00 1.00 1.00 15 1416 2 0 0 2 0
RFA_00446 0.97 0.93 1.00 14 1471 2 0 0 2 1
RFA_00604 0.72 0.74 0.70 26 13493 22 2 9 11 9
RFA_00620 0.64 0.62 0.67 24 21909 25 3 9 13 15
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00674 0.71 0.71 0.71 10 1114 5 0 4 1 4
RFA_00675 0.29 0.29 0.31 4 977 9 1 8 0 10
RFA_00677 0.42 0.43 0.43 6 976 9 0 8 1 8
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00703 0.67 0.64 0.69 9 4265 18 1 3 14 5
RFA_00716 -0.01 0.00 0.00 0 935 11 0 11 0 14
RFA_00717 0.64 0.64 0.64 9 889 5 0 5 0 5
RFA_00730 0.69 0.67 0.73 8 892 4 1 2 1 4
RFA_00763 0.75 0.75 0.75 9 891 4 0 3 1 3
RFA_00765 0.75 0.75 0.75 9 891 5 0 3 2 3
RFA_00770 -0.01 0.00 0.00 0 1999 20 0 17 3 18
RFA_00773 -0.01 0.00 0.00 0 1934 22 0 19 3 18
RFA_00808 1.00 1.00 1.00 16 2000 0 0 0 0 0
SPR_00030 - 0.49 0.43 0.56 9 2469 7 0 7 0 12
SPR_00066 1.00 1.00 1.00 21 2829 1 0 0 1 0
SPR_00228 0.45 0.50 0.42 10 3804 16 5 9 2 10
SPR_00314 0.71 0.76 0.67 16 2902 11 0 8 3 5
SPR_00331 0.46 0.50 0.43 10 2752 13 5 8 0 10
SPR_00333 0.45 0.48 0.43 10 2752 13 5 8 0 11
SPR_00353 1.00 1.00 1.00 21 2829 1 0 0 1 0
SPR_00398 - -0.01 0.00 0.00 0 2193 20 2 16 2 13
SPR_00452 0.53 0.57 0.50 12 2826 12 2 10 0 9
SPR_00456 0.54 0.57 0.52 12 2827 12 2 9 1 9
SPR_00462 0.59 0.58 0.61 11 2397 7 3 4 0 8
SPR_00476 0.42 0.48 0.38 10 2749 17 3 13 1 11
SPR_00496 1.00 1.00 1.00 21 2754 1 0 0 1 0
SPR_00497 0.42 0.48 0.38 10 2749 17 3 13 1 11
SPR_00502 0.56 0.57 0.55 12 2904 10 2 8 0 9
SPR_00509 1.00 1.00 1.00 20 2906 2 0 0 2 0
SPR_00512 1.00 1.00 1.00 20 2906 2 0 0 2 0
SPR_00542 0.28 0.33 0.25 7 3542 21 4 17 0 14
SPR_00557 0.40 0.43 0.39 9 2827 15 1 13 1 12
SPR_00832 - 0.64 0.67 0.63 10 1637 6 2 4 0 5
SPR_00868 0.58 0.57 0.60 12 2906 9 0 8 1 9
SPR_00932 0.54 0.57 0.52 12 2827 11 1 10 0 9
SPR_00957 0.78 0.76 0.80 16 2983 5 0 4 1 5
SPR_01040 0.83 0.81 0.85 17 2755 4 0 3 1 4
SPR_01143 0.32 0.33 0.32 7 2534 15 3 12 0 14
SRP_00005 - 0.82 0.83 0.80 20 3980 7 0 5 2 4
SRP_00038 0.94 0.94 0.94 31 5017 2 0 2 0 2
SRP_00046 0.97 0.97 0.97 31 4721 2 0 1 1 1
SRP_00138 - 1.00 1.00 1.00 27 3978 6 0 0 6 0
SRP_00170 0.55 0.56 0.54 14 4069 13 0 12 1 11
SRP_00193 - 0.67 0.67 0.69 24 6868 12 1 10 1 12
SRP_00194 0.77 0.81 0.74 17 3217 6 0 6 0 4
SRP_00200 0.92 0.94 0.89 34 6865 4 1 3 0 2
SRP_00216 0.93 0.93 0.93 25 3376 3 1 1 1 2
SRP_00229 0.43 0.44 0.41 12 5224 17 5 12 0 15
SRP_00233 0.97 0.94 1.00 31 5120 0 0 0 0 2
SRP_00243 0.97 0.94 1.00 29 5122 1 0 0 1 2
SRP_00244 0.92 0.90 0.95 35 6866 3 1 1 1 4
SRP_00266 0.71 0.72 0.70 21 4626 10 1 8 1 8
SRP_00269 0.59 0.61 0.57 20 5015 15 3 12 0 13
SRP_00273 0.91 0.93 0.90 37 6745 6 1 3 2 3
SRP_00285 0.91 0.87 0.96 26 3714 1 0 1 0 4
SRP_00303 0.69 0.72 0.66 23 6635 12 1 11 0 9
SRP_00333 0.86 0.85 0.88 29 5118 4 0 4 0 5
SRP_00338 0.94 0.94 0.94 34 5424 2 0 2 0 2
SRP_00342 0.55 0.56 0.54 14 3979 17 1 11 5 11
SRP_00358 0.93 0.91 0.94 32 6294 3 1 1 1 3
SRP_00383 0.12 0.13 0.13 3 3216 21 3 18 0 21

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Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP 1070
Total TN 417065
Total FP 2604
Total FP CONTRA 498
Total FP INCONS 1974
Total FP COMP 132
Total FN 1669
Total Scores
MCC 0.339
Average MCC ± 95% Confidence Intervals 0.390 ± 0.054
Sensitivity 0.391
Positive Predictive Value 0.302
Nr of predictions 117

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2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_01535 0.20 0.24 0.17 9 7088 43 7 36 0 28
CRW_01539 0.10 0.11 0.10 4 7099 40 1 36 3 33
CRW_01563 0.11 0.14 0.11 5 6856 43 5 37 1 32
CRW_01583 0.36 0.41 0.33 15 7095 31 8 22 1 22
CRW_01590 -0.01 0.00 0.00 0 7093 50 7 40 3 37
CRW_01593 0.32 0.38 0.29 14 7091 36 5 30 1 23
CRW_01595 -0.01 0.00 0.00 0 8459 57 10 46 1 37
CRW_01603 0.41 0.46 0.38 17 7095 29 6 22 1 20
CRW_01617 0.20 0.24 0.17 9 7087 45 7 37 1 28
CRW_01625 0.43 0.49 0.38 18 7093 31 7 22 2 19
PDB_00011 - 0.96 0.92 1.00 11 265 0 0 0 0 1
PDB_00017 - 0.66 0.67 0.67 10 688 5 1 4 0 5
PDB_00036 - -0.01 0.00 0.00 0 3457 29 1 28 0 27
PDB_00070 0.25 0.29 0.23 7 2819 24 4 20 0 17
PDB_00113 - 0.94 0.89 1.00 8 223 0 0 0 0 1
PDB_00119 - 0.95 0.90 1.00 9 244 0 0 0 0 1
PDB_00136 - 0.70 0.73 0.68 19 2387 9 1 8 0 7
PDB_00137 - 0.87 0.77 1.00 10 396 0 0 0 0 3
PDB_00160 - 0.89 0.89 0.89 8 267 2 0 1 1 1
PDB_00178 - -0.02 0.00 0.00 0 517 11 1 10 0 11
PDB_00221 - 0.94 0.89 1.00 8 245 0 0 0 0 1
PDB_00312 - 1.00 1.00 1.00 9 426 1 0 0 1 0
PDB_00326 - 0.58 0.64 0.53 18 3707 16 4 12 0 10
PDB_00341 - 0.47 0.44 0.54 7 690 6 0 6 0 9
PDB_00349 - 0.10 0.14 0.10 2 926 18 0 18 0 12
PDB_00417 - 0.00 0.00 0.00 0 14138 58 2 56 0 56
PDB_00430 0.38 0.44 0.34 11 3208 21 6 15 0 14
PDB_00527 - -0.02 0.00 0.00 0 292 8 2 6 0 5
PDB_00565 - 0.24 0.24 0.24 12 8079 37 1 36 0 38
PDB_00570 - -0.01 0.00 0.00 0 2257 21 0 21 0 22
PDB_00571 -0.01 0.00 0.00 0 3286 36 6 29 1 25
PDB_00573 - -0.01 0.00 0.00 0 6622 48 5 43 0 34
PDB_00584 - 0.47 0.53 0.43 9 1464 12 1 11 0 8
PDB_00698 - 0.97 0.95 1.00 18 843 0 0 0 0 1
PDB_00725 - 0.82 0.80 0.86 12 581 2 0 2 0 3
PDB_00734 - 0.83 0.70 1.00 7 224 0 0 0 0 3
PDB_00823 - -0.04 0.00 0.00 0 183 7 0 7 0 9
PDB_00828 0.30 0.33 0.28 9 2453 23 0 23 0 18
PDB_00851 - 0.16 0.17 0.17 7 4711 35 3 32 0 34
PDB_00890 - -0.02 0.00 0.00 0 690 13 2 11 0 14
PDB_00923 - 1.00 1.00 1.00 6 184 2 0 0 2 0
PDB_00994 - 0.40 0.50 0.33 21 10521 44 13 30 1 21
PDB_01009 0.27 0.33 0.23 7 2455 25 3 20 2 14
PDB_01051 -0.02 0.00 0.00 0 885 18 1 17 0 13
PDB_01074 - -0.01 0.00 0.00 0 2747 28 3 25 0 25
PDB_01130 - -0.01 0.00 0.00 0 1742 28 5 23 0 20
PDB_01199 - -0.01 0.00 0.00 0 2116 29 2 27 0 24
PDB_01236 0.31 0.33 0.30 18 11568 43 3 39 1 36
RFA_00416 0.94 1.00 0.88 15 1468 6 2 0 4 0
RFA_00434 0.84 1.00 0.71 15 1410 8 6 0 2 0
RFA_00436 0.86 1.00 0.75 15 1411 7 5 0 2 0
RFA_00442 0.94 1.00 0.88 15 1414 4 2 0 2 0
RFA_00446 0.85 0.93 0.78 14 1467 7 3 1 3 1
RFA_00604 0.42 0.54 0.33 19 13472 53 14 25 14 16
RFA_00620 0.16 0.23 0.11 9 21864 80 29 43 8 30
RFA_00664 -0.01 0.00 0.00 0 978 13 0 12 1 14
RFA_00674 0.12 0.14 0.13 2 1112 15 0 14 1 12
RFA_00675 0.28 0.29 0.29 4 976 10 1 9 0 10
RFA_00677 0.62 0.64 0.60 9 975 10 0 6 4 5
RFA_00684 0.74 0.71 0.77 10 977 5 2 1 2 4
RFA_00703 0.26 0.36 0.19 5 4252 32 5 16 11 9
RFA_00716 -0.02 0.00 0.00 0 929 17 0 17 0 14
RFA_00717 0.64 0.64 0.64 9 889 5 2 3 0 5
RFA_00730 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00763 0.38 0.42 0.36 5 889 10 3 6 1 7
RFA_00765 0.39 0.42 0.38 5 890 9 2 6 1 7
RFA_00770 -0.01 0.00 0.00 0 1996 24 0 20 4 18
RFA_00773 0.93 1.00 0.86 18 1932 9 3 0 6 0
RFA_00808 0.83 1.00 0.70 16 1993 7 7 0 0 0
SPR_00030 - 0.47 0.52 0.42 11 2459 16 2 13 1 10
SPR_00066 0.47 0.57 0.39 12 2819 20 4 15 1 9
SPR_00228 0.44 0.60 0.32 12 3791 26 15 10 1 8
SPR_00314 0.47 0.57 0.39 12 2895 21 9 10 2 9
SPR_00331 0.48 0.60 0.39 12 2744 19 6 13 0 8
SPR_00333 0.25 0.33 0.21 7 2741 27 10 17 0 14
SPR_00353 0.64 0.81 0.52 17 2817 16 8 8 0 4
SPR_00398 - -0.01 0.00 0.00 0 2185 28 10 16 2 13
SPR_00452 0.27 0.33 0.23 7 2820 24 7 16 1 14
SPR_00456 0.49 0.57 0.43 12 2822 19 5 11 3 9
SPR_00462 0.65 0.74 0.58 14 2391 11 4 6 1 5
SPR_00476 0.47 0.52 0.42 11 2749 17 4 11 2 10
SPR_00496 0.47 0.57 0.40 12 2745 22 7 11 4 9
SPR_00497 0.27 0.33 0.23 7 2745 23 5 18 0 14
SPR_00502 0.27 0.33 0.23 7 2896 26 2 21 3 14
SPR_00509 0.23 0.30 0.19 6 2895 25 8 17 0 14
SPR_00512 0.61 0.75 0.50 15 2896 15 6 9 0 5
SPR_00542 0.26 0.33 0.22 7 3538 28 4 21 3 14
SPR_00557 0.42 0.52 0.34 11 2818 22 8 13 1 10
SPR_00832 - 0.53 0.67 0.43 10 1630 13 5 8 0 5
SPR_00868 0.49 0.57 0.43 12 2898 19 5 11 3 9
SPR_00932 0.43 0.52 0.35 11 2819 21 7 13 1 10
SPR_00957 0.63 0.76 0.53 16 2973 15 7 7 1 5
SPR_01040 0.15 0.19 0.13 4 2744 27 4 23 0 17
SPR_01143 0.41 0.48 0.36 10 2528 18 8 10 0 11
SRP_00005 - -0.01 0.00 0.00 0 3966 39 6 33 0 24
SRP_00038 0.23 0.27 0.20 9 5005 36 1 35 0 24
SRP_00046 0.33 0.38 0.29 12 4712 30 3 26 1 20
SRP_00138 - 0.44 0.52 0.39 14 3969 24 8 14 2 13
SRP_00170 0.29 0.36 0.25 9 4059 28 4 23 1 16
SRP_00193 - 0.16 0.19 0.15 7 6855 43 4 37 2 29
SRP_00194 0.27 0.33 0.23 7 3209 27 5 19 3 14
SRP_00200 0.41 0.47 0.35 17 6855 31 4 27 0 19
SRP_00216 0.44 0.48 0.41 13 3371 19 4 15 0 14
SRP_00229 0.42 0.52 0.35 14 5213 26 8 18 0 13
SRP_00233 0.25 0.30 0.22 10 5106 35 4 31 0 23
SRP_00243 0.47 0.55 0.40 17 5109 25 7 18 0 14
SRP_00244 0.38 0.44 0.34 17 6853 33 2 31 0 22
SRP_00266 0.55 0.66 0.46 19 4615 22 8 14 0 10
SRP_00269 0.46 0.52 0.43 17 5010 24 6 17 1 16
SRP_00273 0.36 0.40 0.33 16 6737 34 6 27 1 24
SRP_00285 0.38 0.43 0.35 13 3704 24 6 18 0 17
SRP_00303 0.36 0.41 0.33 13 6630 27 3 24 0 19
SRP_00333 0.20 0.24 0.19 8 5108 35 3 32 0 26
SRP_00338 0.52 0.56 0.49 20 5419 22 4 17 1 16
SRP_00342 0.20 0.24 0.17 6 3970 29 7 22 0 19
SRP_00358 0.32 0.37 0.28 13 6282 33 4 29 0 22
SRP_00383 -0.01 0.00 0.00 0 3205 35 9 26 0 24

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.