CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of IPknot - scored higher in this pairwise comparison

  4. Performance of CMfinder(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for IPknot & CMfinder(seed) [.zip] - may take several seconds...


Overview

Metric IPknot CMfinder(seed)
MCC 0.700 > 0.486
Average MCC ± 95% Confidence Intervals 0.629 ± 0.053 > 0.505 ± 0.044
Sensitivity 0.661 > 0.312
Positive Predictive Value 0.742 < 0.757
Total TP 4031 > 1905
Total TN 2878319 < 2881233
Total FP 1775 > 688
Total FP CONTRA 267 > 40
Total FP INCONS 1133 > 572
Total FP COMP 375 > 76
Total FN 2066 < 4192
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of IPknot and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP 4031
Total TN 2878319
Total FP 1775
Total FP CONTRA 267
Total FP INCONS 1133
Total FP COMP 375
Total FN 2066
Total Scores
MCC 0.700
Average MCC ± 95% Confidence Intervals 0.629 ± 0.053
Sensitivity 0.661
Positive Predictive Value 0.742
Nr of predictions 129

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.33 0.26 0.42 30 103669 55 7 34 14 85
CRW_00016 0.75 0.67 0.83 80 77325 26 6 10 10 40
CRW_00610 0.61 0.54 0.68 44 36250 21 6 15 0 37
CRW_00613 0.86 0.78 0.94 61 34915 13 1 3 9 17
CRW_00614 0.13 0.14 0.13 8 121707 95 15 41 39 49
CRW_00618 0.25 0.25 0.26 15 56223 56 5 37 14 46
CRW_00633 0.64 0.58 0.72 61 63461 25 5 19 1 45
CRW_00634 0.60 0.56 0.65 53 64538 30 10 19 1 41
CRW_00670 0.83 0.78 0.87 94 70017 14 6 8 0 26
CRW_00671 0.82 0.74 0.92 86 62742 8 1 6 1 31
CRW_00672 0.76 0.72 0.80 80 72290 24 8 12 4 31
CRW_00674 0.75 0.69 0.83 85 83333 20 7 11 2 39
CRW_00676 0.47 0.44 0.51 51 93428 52 14 35 3 64
CRW_00692 0.56 0.47 0.68 42 68573 21 7 13 1 48
PDB_00005 0.71 0.71 0.71 10 932 4 0 4 0 4
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.94 0.88 1.00 36 5014 0 0 0 0 5
PDB_00553 1.00 1.00 1.00 11 454 0 0 0 0 0
PDB_00716 -0.01 0.00 0.00 0 2680 21 0 21 0 23
PDB_00810 0.91 0.82 1.00 14 1067 0 0 0 0 3
PDB_00827 0.79 0.65 0.95 53 26972 5 0 3 2 28
PDB_01050 0.92 0.85 1.00 11 619 2 0 0 2 2
PDB_01051 0.96 0.92 1.00 12 891 4 0 0 4 1
PDB_01092 0.73 0.63 0.85 33 10114 8 1 5 2 19
PDB_01152 0.88 0.79 1.00 11 550 0 0 0 0 3
RFA_00603 0.68 0.71 0.66 25 13492 15 4 9 2 10
RFA_00604 0.75 0.74 0.76 26 13496 19 2 6 11 9
RFA_00605 0.36 0.34 0.39 12 15194 27 2 17 8 23
RFA_00606 0.69 0.67 0.72 26 21285 20 7 3 10 13
RFA_00607 0.91 0.83 1.00 30 17736 7 0 0 7 6
RFA_00609 0.87 0.89 0.85 33 17916 14 2 4 8 4
RFA_00610 0.90 0.86 0.94 32 17171 12 0 2 10 5
RFA_00611 0.86 0.74 1.00 26 13015 0 0 0 0 9
RFA_00613 0.61 0.49 0.77 17 12858 5 4 1 0 18
RFA_00615 0.71 0.66 0.77 23 13336 7 3 4 0 12
RFA_00620 0.60 0.59 0.61 23 21907 28 1 14 13 16
RFA_00626 0.89 0.85 0.94 74 56537 14 0 5 9 13
RFA_00627 0.69 0.66 0.73 57 56875 35 4 17 14 30
RFA_00628 0.95 0.90 1.00 77 57214 14 0 0 14 9
RFA_00630 0.82 0.75 0.89 65 56880 14 0 8 6 22
RFA_00632 0.42 0.36 0.50 10 4075 11 0 10 1 18
RFA_00636 0.65 0.64 0.67 18 3978 9 3 6 0 10
RFA_00639 0.46 0.45 0.48 39 54533 46 8 35 3 48
RFA_00642 0.21 0.17 0.27 3 2915 8 0 8 0 15
RFA_00643 0.19 0.17 0.23 3 2198 10 0 10 0 15
RFA_00644 0.28 0.22 0.36 4 2690 7 4 3 0 14
RFA_00645 -0.01 0.00 0.00 0 2405 10 2 8 0 18
RFA_00649 0.53 0.28 1.00 5 2140 0 0 0 0 13
RFA_00651 0.31 0.22 0.44 4 2071 6 0 5 1 14
RFA_00653 0.35 0.33 0.38 6 2129 10 2 8 0 12
RFA_00654 -0.01 0.00 0.00 0 2400 15 2 13 0 18
RFA_00658 0.59 0.50 0.70 7 1118 5 0 3 2 7
RFA_00659 -0.01 0.00 0.00 0 1120 10 1 7 2 14
RFA_00664 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00667 0.29 0.29 0.31 4 977 10 1 8 1 10
RFA_00668 0.65 0.43 1.00 6 984 0 0 0 0 8
RFA_00672 -0.01 0.00 0.00 0 897 6 0 6 0 13
RFA_00673 0.47 0.36 0.63 5 1120 4 0 3 1 9
RFA_00674 0.46 0.43 0.50 6 1116 7 0 6 1 8
RFA_00675 -0.01 0.00 0.00 0 980 11 0 10 1 14
RFA_00677 0.48 0.43 0.55 6 979 6 0 5 1 8
RFA_00678 0.53 0.29 1.00 4 942 0 0 0 0 10
RFA_00680 0.74 0.71 0.77 10 1115 6 0 3 3 4
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.50 0.36 0.71 5 983 3 0 2 1 9
RFA_00704 0.00 0.00 0.00 0 990 0 0 0 0 14
RFA_00705 0.74 0.71 0.77 10 1022 4 0 3 1 4
RFA_00706 0.37 0.29 0.50 4 1027 4 0 4 0 10
RFA_00707 -0.01 0.00 0.00 0 1030 5 0 5 0 14
RFA_00708 0.40 0.29 0.57 4 1028 3 0 3 0 10
RFA_00709 -0.01 0.00 0.00 0 982 9 0 8 1 14
RFA_00710 0.08 0.07 0.11 1 981 9 0 8 1 13
RFA_00711 -0.01 0.00 0.00 0 1024 11 0 11 0 14
RFA_00715 -0.01 0.00 0.00 0 936 10 0 10 0 14
RFA_00716 -0.01 0.00 0.00 0 939 7 0 7 0 14
RFA_00717 0.80 0.64 1.00 9 894 0 0 0 0 5
RFA_00730 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00731 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00733 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00734 0.78 0.75 0.82 9 892 3 0 2 1 3
RFA_00736 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00737 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00745 1.00 1.00 1.00 12 934 1 0 0 1 0
RFA_00749 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00758 0.96 0.92 1.00 11 892 0 0 0 0 1
RFA_00762 0.64 0.67 0.62 8 890 5 1 4 0 4
RFA_00763 1.00 1.00 1.00 12 891 0 0 0 0 0
RFA_00764 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00765 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00769 0.54 0.56 0.53 10 1934 9 4 5 0 8
RFA_00770 0.64 0.50 0.82 9 2005 4 0 2 2 9
RFA_00773 0.61 0.56 0.67 10 1938 8 1 4 3 8
RFA_00779 0.74 0.56 1.00 10 1943 0 0 0 0 8
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.34 0.31 0.38 10 5024 16 1 15 0 22
RFA_00791 0.54 0.56 0.53 18 5117 16 6 10 0 14
RFA_00792 0.91 0.91 0.91 29 5018 3 2 1 0 3
RFA_00801 0.85 0.81 0.90 26 5021 4 0 3 1 6
RFA_00808 0.75 0.56 1.00 9 2007 0 0 0 0 7
RFA_00809 0.47 0.38 0.60 6 2135 4 0 4 0 10
RFA_00814 0.89 0.88 0.90 36 25160 11 0 4 7 5
RFA_00815 0.57 0.61 0.54 25 24485 28 5 16 7 16
RFA_00816 0.82 0.85 0.80 35 23176 12 8 1 3 6
RFA_00817 0.23 0.24 0.22 10 21900 38 11 24 3 31
RFA_00818 0.69 0.68 0.70 28 20261 15 9 3 3 13
RFA_00819 0.96 0.95 0.98 39 27926 26 0 1 25 2
SRP_00016 0.94 0.93 0.95 101 47789 7 0 5 2 8
SRP_00130 0.67 0.67 0.67 65 49673 37 4 28 5 32
SRP_00142 0.44 0.44 0.45 41 45965 52 7 43 2 52
SRP_00143 0.73 0.73 0.73 74 49669 33 1 26 6 27
SRP_00144 0.76 0.73 0.78 69 46577 26 1 18 7 25
SRP_00197 0.68 0.57 0.82 58 49384 13 4 9 0 43
SRP_00198 0.57 0.54 0.60 56 50946 39 6 32 1 47
SRP_00199 0.69 0.65 0.73 68 50947 26 1 24 1 37
SRP_00201 0.91 0.91 0.91 101 47784 12 4 6 2 10
SRP_00202 0.97 0.96 0.97 112 54170 4 0 3 1 5
SRP_00203 0.81 0.82 0.80 86 48720 30 1 21 8 19
SRP_00204 0.78 0.76 0.80 78 49043 21 5 15 1 24
SRP_00206 0.88 0.85 0.90 92 47793 11 5 5 1 16
SRP_00208 0.85 0.84 0.87 85 46567 15 3 10 2 16
SRP_00255 0.70 0.69 0.71 65 47495 29 1 25 3 29
SRP_00276 0.94 0.95 0.93 104 50609 9 5 3 1 6
SRP_00278 0.74 0.72 0.75 76 45955 27 3 22 2 29
SRP_00321 0.77 0.77 0.77 83 47478 27 2 23 2 25
SRP_00322 0.85 0.87 0.83 95 48402 21 4 15 2 14
SRP_00323 0.91 0.90 0.91 96 47173 12 0 9 3 11
SRP_00330 0.60 0.62 0.57 59 49983 50 4 40 6 36
SRP_00332 0.92 0.92 0.92 98 50296 10 2 7 1 8
SRP_00339 0.68 0.69 0.67 65 44454 37 5 27 5 29

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 1905
Total TN 2881233
Total FP 688
Total FP CONTRA 40
Total FP INCONS 572
Total FP COMP 76
Total FN 4192
Total Scores
MCC 0.486
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044
Sensitivity 0.312
Positive Predictive Value 0.757
Nr of predictions 129

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.37 0.14 1.00 16 103724 0 0 0 0 99
CRW_00016 0.36 0.14 0.89 17 77402 2 0 2 0 103
CRW_00610 0.49 0.31 0.78 25 36283 7 1 6 0 56
CRW_00613 0.54 0.33 0.87 26 34950 4 0 4 0 52
CRW_00614 0.46 0.25 0.88 14 121755 9 0 2 7 43
CRW_00618 0.36 0.13 1.00 8 56272 0 0 0 0 53
CRW_00633 0.32 0.12 0.81 13 63530 3 1 2 0 93
CRW_00634 0.40 0.17 0.94 16 64603 1 0 1 0 78
CRW_00670 0.32 0.18 0.55 22 70085 18 0 18 0 98
CRW_00671 0.20 0.09 0.41 11 62808 16 0 16 0 106
CRW_00672 0.38 0.15 0.94 17 72372 1 0 1 0 94
CRW_00674 0.40 0.17 0.95 21 83414 1 0 1 0 103
CRW_00676 0.12 0.04 0.33 5 93513 10 1 9 0 110
CRW_00692 0.41 0.17 1.00 15 68620 0 0 0 0 75
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_00810 0.76 0.59 1.00 10 1071 0 0 0 0 7
PDB_00827 0.25 0.10 0.62 8 27015 5 0 5 0 73
PDB_01050 0.68 0.46 1.00 6 624 1 0 0 1 7
PDB_01051 0.83 0.69 1.00 9 894 4 0 0 4 4
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00603 0.70 0.60 0.81 21 13504 7 0 5 2 14
RFA_00604 0.63 0.51 0.78 18 13507 8 0 5 3 17
RFA_00605 0.14 0.06 0.33 2 15219 5 0 4 1 33
RFA_00606 0.34 0.21 0.57 8 21307 8 2 4 2 31
RFA_00607 0.08 0.06 0.13 2 17750 15 3 11 1 34
RFA_00609 0.32 0.22 0.47 8 17938 12 2 7 3 29
RFA_00610 0.39 0.30 0.52 11 17184 13 2 8 3 26
RFA_00611 0.65 0.51 0.82 18 13019 5 0 4 1 17
RFA_00613 0.70 0.57 0.87 20 12857 4 0 3 1 15
RFA_00615 0.57 0.49 0.68 17 13341 10 0 8 2 18
RFA_00620 0.00 0.00 0.00 0 21939 6 0 6 0 39
RFA_00626 0.44 0.32 0.60 28 56569 22 2 17 3 59
RFA_00627 0.53 0.39 0.72 34 56906 15 3 10 2 53
RFA_00628 0.58 0.43 0.77 37 57243 14 3 8 3 49
RFA_00630 0.45 0.32 0.64 28 56909 17 3 13 1 59
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00639 0.00 0.00 0.00 0 54575 44 6 34 4 87
RFA_00642 0.44 0.28 0.71 5 2919 2 0 2 0 13
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.00 0.00 0.00 0 2693 8 0 8 0 18
RFA_00645 0.29 0.17 0.50 3 2409 3 0 3 0 15
RFA_00649 0.35 0.22 0.57 4 2138 3 0 3 0 14
RFA_00651 0.35 0.22 0.57 4 2073 3 0 3 0 14
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.38 0.22 0.67 4 2409 2 0 2 0 14
RFA_00658 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00659 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00664 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00667 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00668 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00672 0.41 0.31 0.57 4 896 3 0 3 0 9
RFA_00673 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00674 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00675 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00677 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00704 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00705 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00710 0.32 0.21 0.50 3 984 3 0 3 0 11
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.30 0.14 0.67 2 943 2 0 1 1 12
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.30 0.21 0.43 3 896 4 0 4 0 11
RFA_00730 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00731 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00733 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00734 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00736 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00737 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00745 0.91 0.83 1.00 10 936 0 0 0 0 2
RFA_00749 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00758 0.86 0.75 1.00 9 894 0 0 0 0 3
RFA_00762 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00763 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00764 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00765 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00791 0.92 0.88 0.97 28 5122 1 0 1 0 4
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10
RFA_00814 0.68 0.51 0.91 21 25177 2 0 2 0 20
RFA_00815 0.68 0.51 0.91 21 24508 2 0 2 0 20
RFA_00816 0.68 0.51 0.91 21 23197 2 0 2 0 20
RFA_00817 0.68 0.56 0.82 23 21917 5 0 5 0 18
RFA_00818 0.60 0.49 0.74 20 20274 8 1 6 1 21
RFA_00819 0.62 0.51 0.75 21 27938 7 0 7 0 20
SRP_00016 0.54 0.35 0.83 38 47849 8 0 8 0 71
SRP_00130 0.50 0.32 0.78 31 49730 10 1 8 1 66
SRP_00142 0.46 0.37 0.58 34 45997 26 1 24 1 59
SRP_00143 0.50 0.30 0.86 30 49735 5 0 5 0 71
SRP_00144 0.54 0.37 0.80 35 46621 11 0 9 2 59
SRP_00197 0.46 0.26 0.84 26 49424 5 0 5 0 75
SRP_00198 0.56 0.37 0.84 38 50995 7 0 7 0 65
SRP_00199 0.54 0.35 0.82 37 50995 8 0 8 0 68
SRP_00201 0.54 0.35 0.83 39 47848 8 0 8 0 72
SRP_00202 0.43 0.21 0.86 25 54256 4 0 4 0 92
SRP_00203 0.51 0.34 0.77 36 48781 12 0 11 1 69
SRP_00204 0.52 0.34 0.80 35 49097 9 1 8 0 67
SRP_00206 0.55 0.36 0.83 39 47848 8 0 8 0 69
SRP_00208 0.52 0.33 0.83 33 46625 7 1 6 0 68
SRP_00255 0.49 0.27 0.89 25 47558 3 0 3 0 69
SRP_00276 0.51 0.33 0.80 36 50676 9 0 9 0 74
SRP_00278 0.52 0.33 0.81 35 46013 8 0 8 0 70
SRP_00321 0.42 0.21 0.82 23 47558 5 1 4 0 85
SRP_00322 0.52 0.33 0.82 36 48472 8 0 8 0 73
SRP_00323 0.54 0.34 0.88 36 47237 5 0 5 0 71
SRP_00330 0.44 0.23 0.85 22 50060 5 0 4 1 73
SRP_00332 0.44 0.25 0.75 27 50367 9 0 9 0 79
SRP_00339 0.56 0.39 0.79 37 44504 10 2 8 0 57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.