CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MCFold		PPfold(seed)
MCC	0.421	>	0.417
Average MCC ± 95% Confidence Intervals	0.443 ± 0.099	>	0.343 ± 0.128
Sensitivity	0.478	>	0.206
Positive Predictive Value	0.378	<	0.852
Total TP	362	>	156
Total TN	101542	<	102316
Total FP	724	>	34
Total FP CONTRA	95	>	6
Total FP INCONS	500	>	21
Total FP COMP	129	>	7
Total FN	395	<	601
P-value	0.135703339508

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Performance plots

Comparison of performance of MCFold and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MCFold and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MCFold and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MCFold and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MCFold and PPfold(seed)).

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Performance of MCFold - scored higher in this pairwise comparison

1. Total counts & total scores for MCFold

Total Base Pair Counts
Total TP	362
Total TN	101542
Total FP	724
Total FP CONTRA	95
Total FP INCONS	500
Total FP COMP	129
Total FN	395

Total Scores
MCC	0.421
Average MCC ± 95% Confidence Intervals	0.443 ± 0.099
Sensitivity	0.478
Positive Predictive Value	0.378
Nr of predictions	35

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2. Individual counts for MCFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.29	0.39	0.23	7	2115	23	9	14	0	11
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	8	0	0	8	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	9	0	0	9	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	8	0	0	8	0
RFA_00654	Vimentin3 links to Rfam database...	-0.01	0.00	0.00	0	2386	29	4	25	0	18
RFA_00658	Hammerhead_1 links to Rfam database...	0.62	0.64	0.60	9	1113	10	0	6	4	5
RFA_00664	Hammerhead_1 links to Rfam database...	-0.02	0.00	0.00	0	974	16	0	16	0	14
RFA_00708	Hammerhead_1 links to Rfam database...	0.64	0.64	0.64	9	1021	10	0	5	5	5
RFA_00749	s2m links to Rfam database...	0.34	0.42	0.29	5	886	13	4	8	1	7
RFA_00764	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00765	s2m links to Rfam database...	0.72	0.75	0.69	9	890	10	0	4	6	3
RFA_00767	Corona_pk3 links to Rfam database...	0.36	0.44	0.31	8	1865	19	3	15	1	10
RFA_00768	Corona_pk3 links to Rfam database...	0.36	0.44	0.31	8	1865	19	3	15	1	10
RFA_00769	Corona_pk3 links to Rfam database...	0.45	0.50	0.41	9	1931	18	2	11	5	9
RFA_00770	Corona_pk3 links to Rfam database...	-0.01	0.00	0.00	0	1992	29	2	22	5	18
RFA_00773	Corona_pk3 links to Rfam database...	0.43	0.50	0.38	9	1929	16	4	11	1	9
RFA_00779	Corona_pk3 links to Rfam database...	0.45	0.56	0.37	10	1926	17	7	10	0	8
RFA_00808	RydC links to Rfam database...	0.39	0.44	0.35	7	1996	19	1	12	6	9
RFA_00809	RydC links to Rfam database...	0.30	0.38	0.25	6	2121	18	6	12	0	10
SPR_00020	tRNA links to Rfam database...	0.44	0.55	0.37	11	2671	20	5	14	1	9
SPR_00137	tRNA links to Rfam database...	0.50	0.62	0.41	13	2894	22	7	12	3	8
SPR_00394	tRNA links to Rfam database...	0.58	0.62	0.54	13	3631	21	0	11	10	8
SPR_00402	tRNA links to Rfam database...	-0.01	0.00	0.00	0	2525	32	3	28	1	21
SPR_00721	tRNA links to Rfam database...	0.19	0.24	0.16	5	2895	29	1	25	3	16
SPR_00816	tRNA links to Rfam database...	0.27	0.35	0.22	7	3454	29	8	17	4	13
SPR_01157	tRNA links to Rfam database...	0.70	0.76	0.64	16	2750	13	2	7	4	5
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.26	0.29	0.24	10	5524	32	3	28	1	24
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.31	0.38	0.26	11	5953	35	8	23	4	18
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.33	0.37	0.31	15	6280	35	2	31	2	26
SRP_00231	Bacteria_small_SRP links to Rfam database...	-0.01	0.00	0.00	0	5416	44	6	38	0	34
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.75	0.78	0.74	31	6744	18	1	10	7	9
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.77	0.79	0.75	30	6863	18	1	9	8	8
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.33	0.37	0.31	11	3705	27	2	23	2	19
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.32	0.35	0.31	11	4717	31	0	25	6	20
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.76	0.78	0.74	28	5318	17	1	9	7	8

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	156
Total TN	102316
Total FP	34
Total FP CONTRA	6
Total FP INCONS	21
Total FP COMP	7
Total FN	601

Total Scores
MCC	0.417
Average MCC ± 95% Confidence Intervals	0.343 ± 0.128
Sensitivity	0.206
Positive Predictive Value	0.852
Nr of predictions	35

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
PDB_01001	tRNA links to Rfam database...	0.00	0.00	0.00	0	2145	0	0	0	0	18
RFA_00390	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	1	0	0	1	0
RFA_00416	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1470	1	0	0	1	0
RFA_00433	Hammerhead_3 links to Rfam database...	1.00	1.00	1.00	15	1416	2	0	0	2	0
RFA_00654	Vimentin3 links to Rfam database...	0.23	0.17	0.33	3	2406	6	0	6	0	15
RFA_00658	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1126	1	0	0	1	12
RFA_00664	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	988	1	0	0	1	12
RFA_00708	Hammerhead_1 links to Rfam database...	0.38	0.14	1.00	2	1033	1	0	0	1	12
RFA_00749	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00764	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00765	s2m links to Rfam database...	0.78	0.75	0.82	9	892	2	0	2	0	3
RFA_00767	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00768	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1879	2	1	1	0	8
RFA_00769	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00770	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	2004	2	1	1	0	8
RFA_00773	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00779	Corona_pk3 links to Rfam database...	0.68	0.56	0.83	10	1941	2	1	1	0	8
RFA_00808	RydC links to Rfam database...	0.75	0.56	1.00	9	2007	0	0	0	0	7
RFA_00809	RydC links to Rfam database...	0.50	0.38	0.67	6	2136	3	0	3	0	10
SPR_00020	tRNA links to Rfam database...	0.00	0.00	0.00	0	2701	0	0	0	0	20
SPR_00137	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00394	tRNA links to Rfam database...	0.00	0.00	0.00	0	3655	0	0	0	0	21
SPR_00402	tRNA links to Rfam database...	0.00	0.00	0.00	0	2556	0	0	0	0	21
SPR_00721	tRNA links to Rfam database...	0.00	0.00	0.00	0	2926	0	0	0	0	21
SPR_00816	tRNA links to Rfam database...	0.00	0.00	0.00	0	3486	0	0	0	0	20
SPR_01157	tRNA links to Rfam database...	0.00	0.00	0.00	0	2775	0	0	0	0	21
SRP_00105	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5565	0	0	0	0	34
SRP_00134	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	5995	0	0	0	0	29
SRP_00141	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6328	0	0	0	0	41
SRP_00231	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5460	0	0	0	0	34
SRP_00273	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6786	0	0	0	0	40
SRP_00274	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	6903	0	0	0	0	38
SRP_00285	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	3741	0	0	0	0	30
SRP_00341	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	4753	0	0	0	0	31
SRP_00357	Bacteria_small_SRP links to Rfam database...	0.00	0.00	0.00	0	5356	0	0	0	0	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MCFold - scored higher in this pairwise comparison

1. Total counts & total scores for MCFold

2. Individual counts for MCFold [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]