CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of MXScarna(seed) - scored higher in this pairwise comparison

  4. Performance of CMfinder(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for MXScarna(seed) & CMfinder(seed) [.zip] - may take several seconds...


Overview

Metric MXScarna(seed) CMfinder(seed)
MCC 0.697 > 0.486
Average MCC ± 95% Confidence Intervals 0.686 ± 0.046 > 0.505 ± 0.044
Sensitivity 0.619 > 0.312
Positive Predictive Value 0.785 > 0.757
Total TP 3777 > 1905
Total TN 2878937 < 2881233
Total FP 1689 > 688
Total FP CONTRA 137 > 40
Total FP INCONS 899 > 572
Total FP COMP 653 > 76
Total FN 2320 < 4192
P-value 3.56938820447e-08

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Performance plots


  1. Comparison of performance of MXScarna(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP 3777
Total TN 2878937
Total FP 1689
Total FP CONTRA 137
Total FP INCONS 899
Total FP COMP 653
Total FN 2320
Total Scores
MCC 0.697
Average MCC ± 95% Confidence Intervals 0.686 ± 0.046
Sensitivity 0.619
Positive Predictive Value 0.785
Nr of predictions 129

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.33 0.21 0.53 24 103695 23 4 17 2 91
CRW_00016 0.31 0.19 0.51 23 77376 24 7 15 2 97
CRW_00610 0.16 0.09 0.32 7 36293 15 1 14 0 74
CRW_00613 0.00 0.00 0.00 0 34956 24 7 17 0 78
CRW_00614 0.00 0.00 0.00 0 121749 22 4 18 0 57
CRW_00618 0.18 0.10 0.32 6 56261 13 1 12 0 55
CRW_00633 0.45 0.27 0.74 29 63507 14 0 10 4 77
CRW_00634 0.47 0.30 0.74 28 64582 18 0 10 8 66
CRW_00670 0.47 0.26 0.86 31 70089 7 0 5 2 89
CRW_00671 0.56 0.37 0.84 43 62784 10 0 8 2 74
CRW_00672 0.43 0.28 0.67 31 72344 17 0 15 2 80
CRW_00674 0.22 0.14 0.37 17 83390 29 5 24 0 107
CRW_00676 0.03 0.02 0.07 2 93500 31 4 22 5 113
CRW_00692 0.03 0.01 0.06 1 68619 22 0 15 7 89
PDB_00005 0.59 0.36 1.00 5 941 0 0 0 0 9
PDB_00012 1.00 1.00 1.00 7 399 3 0 0 3 0
PDB_00213 0.81 0.73 0.91 30 5017 3 0 3 0 11
PDB_00553 0.90 0.82 1.00 9 456 0 0 0 0 2
PDB_00716 -0.01 0.00 0.00 0 2681 21 1 19 1 23
PDB_00810 0.77 0.65 0.92 11 1069 2 0 1 1 6
PDB_00827 0.00 0.00 0.00 0 27011 17 1 16 0 81
PDB_01050 0.78 0.62 1.00 8 622 2 0 0 2 5
PDB_01051 0.64 0.54 0.78 7 894 5 0 2 3 6
PDB_01092 0.70 0.63 0.79 33 10111 12 2 7 3 19
PDB_01152 0.85 0.79 0.92 11 549 1 0 1 0 3
RFA_00603 0.74 0.74 0.74 26 13495 17 3 6 8 9
RFA_00604 0.72 0.63 0.81 22 13503 13 3 2 8 13
RFA_00605 0.26 0.23 0.30 8 15198 22 5 14 3 27
RFA_00606 0.53 0.51 0.56 20 21285 25 4 12 9 19
RFA_00607 0.77 0.72 0.81 26 17734 16 1 5 10 10
RFA_00609 0.67 0.65 0.69 24 17920 19 2 9 8 13
RFA_00610 0.76 0.76 0.76 28 17168 19 1 8 10 9
RFA_00611 0.75 0.74 0.76 26 13007 13 4 4 5 9
RFA_00613 0.76 0.71 0.81 25 12849 11 4 2 5 10
RFA_00615 0.75 0.74 0.76 26 13332 15 4 4 7 9
RFA_00620 0.20 0.18 0.23 7 21915 33 7 16 10 32
RFA_00626 0.89 0.87 0.92 76 56533 29 2 5 22 11
RFA_00627 0.83 0.79 0.87 69 56874 36 1 9 26 18
RFA_00628 0.85 0.81 0.89 70 57212 38 2 7 29 16
RFA_00630 0.82 0.78 0.86 68 56874 33 2 9 22 19
RFA_00632 0.25 0.25 0.27 7 4069 19 1 18 0 21
RFA_00636 0.35 0.36 0.36 10 3977 18 2 16 0 18
RFA_00639 0.31 0.31 0.31 27 54527 69 10 51 8 60
RFA_00642 0.56 0.50 0.64 9 2912 7 0 5 2 9
RFA_00643 0.69 0.61 0.79 11 2197 5 0 3 2 7
RFA_00644 0.69 0.61 0.79 11 2687 5 0 3 2 7
RFA_00645 0.30 0.28 0.33 5 2400 11 0 10 1 13
RFA_00649 0.73 0.67 0.80 12 2130 5 0 3 2 6
RFA_00651 0.73 0.67 0.80 12 2065 5 0 3 2 6
RFA_00653 0.67 0.61 0.73 11 2130 6 0 4 2 7
RFA_00654 0.73 0.67 0.80 12 2400 5 0 3 2 6
RFA_00658 0.61 0.57 0.67 8 1116 5 0 4 1 6
RFA_00659 0.46 0.43 0.50 6 1116 7 0 6 1 8
RFA_00664 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00667 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00668 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00672 0.72 0.69 0.75 9 891 4 0 3 1 4
RFA_00673 0.61 0.57 0.67 8 1116 5 0 4 1 6
RFA_00674 0.69 0.64 0.75 9 1116 4 0 3 1 5
RFA_00675 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00677 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00678 0.66 0.64 0.69 9 933 5 0 4 1 5
RFA_00680 0.61 0.57 0.67 8 1116 5 0 4 1 6
RFA_00684 0.66 0.64 0.69 9 977 5 0 4 1 5
RFA_00685 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00704 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00705 0.66 0.64 0.69 9 1022 5 0 4 1 5
RFA_00706 0.69 0.64 0.75 9 1023 4 0 3 1 5
RFA_00707 0.69 0.64 0.75 9 1023 4 0 3 1 5
RFA_00708 0.64 0.57 0.73 8 1024 4 0 3 1 6
RFA_00709 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00710 0.69 0.64 0.75 9 978 4 0 3 1 5
RFA_00711 0.69 0.64 0.75 9 1023 4 0 3 1 5
RFA_00715 0.56 0.50 0.64 7 935 5 0 4 1 7
RFA_00716 0.48 0.43 0.55 6 935 6 0 5 1 8
RFA_00717 0.69 0.64 0.75 9 891 3 0 3 0 5
RFA_00730 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00731 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00733 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00734 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00736 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00737 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00745 1.00 1.00 1.00 12 934 1 0 0 1 0
RFA_00749 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00758 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00762 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00763 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00764 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00765 1.00 1.00 1.00 12 891 1 0 0 1 0
RFA_00769 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00770 0.57 0.56 0.59 10 1999 7 2 5 0 8
RFA_00773 0.55 0.56 0.56 10 1935 8 3 5 0 8
RFA_00779 0.57 0.56 0.59 10 1936 7 2 5 0 8
RFA_00781 0.92 0.91 0.94 29 5019 3 2 0 1 3
RFA_00786 0.92 0.91 0.94 29 5019 3 2 0 1 3
RFA_00791 0.87 0.88 0.88 28 5119 5 2 2 1 4
RFA_00792 0.92 0.91 0.94 29 5019 3 2 0 1 3
RFA_00801 0.91 0.91 0.91 29 5018 4 2 1 1 3
RFA_00808 -0.01 0.00 0.00 0 2000 19 2 14 3 16
RFA_00809 0.30 0.31 0.29 5 2128 12 1 11 0 11
RFA_00814 0.95 0.93 0.97 38 25161 22 0 1 21 3
RFA_00815 0.96 0.93 1.00 38 24493 15 0 0 15 3
RFA_00816 0.96 0.93 1.00 38 23182 15 0 0 15 3
RFA_00817 0.94 0.88 1.00 36 21909 12 0 0 12 5
RFA_00818 0.64 0.68 0.61 28 20255 30 11 7 12 13
RFA_00819 0.94 0.90 0.97 37 27928 26 0 1 25 4
SRP_00016 0.92 0.89 0.95 97 47793 15 0 5 10 12
SRP_00130 0.74 0.70 0.77 68 49682 35 1 19 15 29
SRP_00142 0.89 0.87 0.90 81 45966 25 0 9 16 12
SRP_00143 0.84 0.83 0.85 84 49671 26 0 15 11 17
SRP_00144 0.87 0.86 0.87 81 46572 28 0 12 16 13
SRP_00197 0.92 0.90 0.94 91 49358 24 0 6 18 10
SRP_00198 0.90 0.87 0.92 90 50942 24 0 8 16 13
SRP_00199 0.89 0.88 0.91 92 50939 21 0 9 12 13
SRP_00201 0.94 0.93 0.96 103 47788 11 0 4 7 8
SRP_00202 0.89 0.85 0.93 100 54178 16 0 7 9 17
SRP_00203 0.83 0.83 0.83 87 48723 25 0 18 7 18
SRP_00204 0.87 0.85 0.88 87 49042 25 0 12 13 15
SRP_00206 0.94 0.93 0.96 100 47791 14 0 4 10 8
SRP_00208 0.91 0.88 0.95 89 46571 20 0 5 15 12
SRP_00255 0.74 0.76 0.73 71 47489 40 1 25 14 23
SRP_00276 0.93 0.91 0.94 100 50615 13 0 6 7 10
SRP_00278 0.73 0.69 0.77 72 45963 26 0 21 5 33
SRP_00321 0.76 0.75 0.78 81 47482 30 0 23 7 27
SRP_00322 0.79 0.75 0.83 82 48417 26 0 17 9 27
SRP_00323 0.85 0.83 0.87 89 47176 22 0 13 9 18
SRP_00330 0.80 0.80 0.81 76 49992 29 2 16 11 19
SRP_00332 0.95 0.93 0.97 99 50301 15 0 3 12 7
SRP_00339 0.78 0.78 0.78 73 44458 27 4 16 7 21

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP 1905
Total TN 2881233
Total FP 688
Total FP CONTRA 40
Total FP INCONS 572
Total FP COMP 76
Total FN 4192
Total Scores
MCC 0.486
Average MCC ± 95% Confidence Intervals 0.505 ± 0.044
Sensitivity 0.312
Positive Predictive Value 0.757
Nr of predictions 129

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
CRW_00013 0.37 0.14 1.00 16 103724 0 0 0 0 99
CRW_00016 0.36 0.14 0.89 17 77402 2 0 2 0 103
CRW_00610 0.49 0.31 0.78 25 36283 7 1 6 0 56
CRW_00613 0.54 0.33 0.87 26 34950 4 0 4 0 52
CRW_00614 0.46 0.25 0.88 14 121755 9 0 2 7 43
CRW_00618 0.36 0.13 1.00 8 56272 0 0 0 0 53
CRW_00633 0.32 0.12 0.81 13 63530 3 1 2 0 93
CRW_00634 0.40 0.17 0.94 16 64603 1 0 1 0 78
CRW_00670 0.32 0.18 0.55 22 70085 18 0 18 0 98
CRW_00671 0.20 0.09 0.41 11 62808 16 0 16 0 106
CRW_00672 0.38 0.15 0.94 17 72372 1 0 1 0 94
CRW_00674 0.40 0.17 0.95 21 83414 1 0 1 0 103
CRW_00676 0.12 0.04 0.33 5 93513 10 1 9 0 110
CRW_00692 0.41 0.17 1.00 15 68620 0 0 0 0 75
PDB_00005 0.47 0.36 0.63 5 938 3 0 3 0 9
PDB_00012 1.00 1.00 1.00 7 399 2 0 0 2 0
PDB_00213 0.85 0.73 1.00 30 5020 0 0 0 0 11
PDB_00553 0.00 0.00 0.00 0 465 0 0 0 0 11
PDB_00716 -0.01 0.00 0.00 0 2688 13 0 13 0 23
PDB_00810 0.76 0.59 1.00 10 1071 0 0 0 0 7
PDB_00827 0.25 0.10 0.62 8 27015 5 0 5 0 73
PDB_01050 0.68 0.46 1.00 6 624 1 0 0 1 7
PDB_01051 0.83 0.69 1.00 9 894 4 0 0 4 4
PDB_01092 0.38 0.21 0.69 11 10137 6 0 5 1 41
PDB_01152 0.92 0.86 1.00 12 549 0 0 0 0 2
RFA_00603 0.70 0.60 0.81 21 13504 7 0 5 2 14
RFA_00604 0.63 0.51 0.78 18 13507 8 0 5 3 17
RFA_00605 0.14 0.06 0.33 2 15219 5 0 4 1 33
RFA_00606 0.34 0.21 0.57 8 21307 8 2 4 2 31
RFA_00607 0.08 0.06 0.13 2 17750 15 3 11 1 34
RFA_00609 0.32 0.22 0.47 8 17938 12 2 7 3 29
RFA_00610 0.39 0.30 0.52 11 17184 13 2 8 3 26
RFA_00611 0.65 0.51 0.82 18 13019 5 0 4 1 17
RFA_00613 0.70 0.57 0.87 20 12857 4 0 3 1 15
RFA_00615 0.57 0.49 0.68 17 13341 10 0 8 2 18
RFA_00620 0.00 0.00 0.00 0 21939 6 0 6 0 39
RFA_00626 0.44 0.32 0.60 28 56569 22 2 17 3 59
RFA_00627 0.53 0.39 0.72 34 56906 15 3 10 2 53
RFA_00628 0.58 0.43 0.77 37 57243 14 3 8 3 49
RFA_00630 0.45 0.32 0.64 28 56909 17 3 13 1 59
RFA_00632 0.27 0.25 0.29 7 4071 17 0 17 0 21
RFA_00636 0.71 0.64 0.78 18 3982 5 2 3 0 10
RFA_00639 0.00 0.00 0.00 0 54575 44 6 34 4 87
RFA_00642 0.44 0.28 0.71 5 2919 2 0 2 0 13
RFA_00643 -0.01 0.00 0.00 0 2203 8 0 8 0 18
RFA_00644 0.00 0.00 0.00 0 2693 8 0 8 0 18
RFA_00645 0.29 0.17 0.50 3 2409 3 0 3 0 15
RFA_00649 0.35 0.22 0.57 4 2138 3 0 3 0 14
RFA_00651 0.35 0.22 0.57 4 2073 3 0 3 0 14
RFA_00653 -0.01 0.00 0.00 0 2137 8 0 8 0 18
RFA_00654 0.38 0.22 0.67 4 2409 2 0 2 0 14
RFA_00658 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00659 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00664 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00667 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00668 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00672 0.41 0.31 0.57 4 896 3 0 3 0 9
RFA_00673 0.23 0.14 0.40 2 1123 4 0 3 1 12
RFA_00674 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00675 0.35 0.21 0.60 3 985 3 0 2 1 11
RFA_00677 0.40 0.29 0.57 4 983 4 0 3 1 10
RFA_00678 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00680 0.40 0.29 0.57 4 1121 4 0 3 1 10
RFA_00684 0.43 0.29 0.67 4 984 3 0 2 1 10
RFA_00685 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00704 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00705 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00706 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00707 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00708 0.40 0.29 0.57 4 1028 4 0 3 1 10
RFA_00709 0.32 0.21 0.50 3 984 4 0 3 1 11
RFA_00710 0.32 0.21 0.50 3 984 3 0 3 0 11
RFA_00711 0.43 0.29 0.67 4 1029 3 0 2 1 10
RFA_00715 0.30 0.14 0.67 2 943 2 0 1 1 12
RFA_00716 0.43 0.29 0.67 4 940 3 0 2 1 10
RFA_00717 0.30 0.21 0.43 3 896 4 0 4 0 11
RFA_00730 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00731 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00733 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00734 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00736 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00737 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00745 0.91 0.83 1.00 10 936 0 0 0 0 2
RFA_00749 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00758 0.86 0.75 1.00 9 894 0 0 0 0 3
RFA_00762 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00763 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00764 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00765 0.91 0.83 1.00 10 893 0 0 0 0 2
RFA_00769 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00770 0.71 0.50 1.00 9 2007 0 0 0 0 9
RFA_00773 0.00 0.00 0.00 0 1949 4 0 4 0 18
RFA_00779 0.71 0.50 1.00 9 1944 0 0 0 0 9
RFA_00781 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00786 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00791 0.92 0.88 0.97 28 5122 1 0 1 0 4
RFA_00792 0.97 0.94 1.00 30 5020 0 0 0 0 2
RFA_00801 0.95 0.91 1.00 29 5021 0 0 0 0 3
RFA_00808 0.68 0.56 0.82 9 2005 2 0 2 0 7
RFA_00809 0.41 0.38 0.46 6 2132 7 1 6 0 10
RFA_00814 0.68 0.51 0.91 21 25177 2 0 2 0 20
RFA_00815 0.68 0.51 0.91 21 24508 2 0 2 0 20
RFA_00816 0.68 0.51 0.91 21 23197 2 0 2 0 20
RFA_00817 0.68 0.56 0.82 23 21917 5 0 5 0 18
RFA_00818 0.60 0.49 0.74 20 20274 8 1 6 1 21
RFA_00819 0.62 0.51 0.75 21 27938 7 0 7 0 20
SRP_00016 0.54 0.35 0.83 38 47849 8 0 8 0 71
SRP_00130 0.50 0.32 0.78 31 49730 10 1 8 1 66
SRP_00142 0.46 0.37 0.58 34 45997 26 1 24 1 59
SRP_00143 0.50 0.30 0.86 30 49735 5 0 5 0 71
SRP_00144 0.54 0.37 0.80 35 46621 11 0 9 2 59
SRP_00197 0.46 0.26 0.84 26 49424 5 0 5 0 75
SRP_00198 0.56 0.37 0.84 38 50995 7 0 7 0 65
SRP_00199 0.54 0.35 0.82 37 50995 8 0 8 0 68
SRP_00201 0.54 0.35 0.83 39 47848 8 0 8 0 72
SRP_00202 0.43 0.21 0.86 25 54256 4 0 4 0 92
SRP_00203 0.51 0.34 0.77 36 48781 12 0 11 1 69
SRP_00204 0.52 0.34 0.80 35 49097 9 1 8 0 67
SRP_00206 0.55 0.36 0.83 39 47848 8 0 8 0 69
SRP_00208 0.52 0.33 0.83 33 46625 7 1 6 0 68
SRP_00255 0.49 0.27 0.89 25 47558 3 0 3 0 69
SRP_00276 0.51 0.33 0.80 36 50676 9 0 9 0 74
SRP_00278 0.52 0.33 0.81 35 46013 8 0 8 0 70
SRP_00321 0.42 0.21 0.82 23 47558 5 1 4 0 85
SRP_00322 0.52 0.33 0.82 36 48472 8 0 8 0 73
SRP_00323 0.54 0.34 0.88 36 47237 5 0 5 0 71
SRP_00330 0.44 0.23 0.85 22 50060 5 0 4 1 73
SRP_00332 0.44 0.25 0.75 27 50367 9 0 9 0 79
SRP_00339 0.56 0.39 0.79 37 44504 10 2 8 0 57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.